George Church, Ph.D. is a professor of genetics at Harvard Medical School and of health sciences and technology at both Harvard and the Massachusetts Institute of Technology. Dr. Church played an instrumental role in the Human Genome Project and is widely recognized as one of the premier scientists in the fields of gene editing technology and synthetic biology. EPISODE LINKS: Show notes and transcript: https://www.foundmyfitness.com/episodes/george-church?utm_source=youtube&utm_medium=youtube&utm_campaign=church_interview Dr. George Church on Twitter: https://twitter.com/geochurch Dr. George Church on Instagram: https://www.instagram.com/george.church Church lab: https://arep.med.harvard.edu/ Regenesis Book: https://www.amazon.com/Regenesis-Synthetic-Biology-Reinvent-Ourselves/dp/0465075703 PODCAST INFO: Email: https://www.foundmyfitness.com/newsletter?utm_source=youtube&utm_medium=youtube&utm_campaign=church_interview Apple Podcasts: https://podcasts.apple.com/us/podcast/foundmyfitness/id818198322 Spotify: https://open.spotify.com/show/5QjpaU0o1Q2MkVZwwG3y7d Full interview playlist: https://www.youtube.com/playlist?list=PLJEEAVzHu9KzgkQbe2Thh35VU-HCiId_s Clips playlist: https://www.youtube.com/playlist?list=PLrGxo-5Uw8gI9-1IStYEvNxVukKxZBlmi CHAPTERS: 00:00:00 Intro 00:02:52 History of the Human Genome Project 00:09:48 Manufacturing cell phones (with biology) 00:13:21 Genome Project-Write 00:15:51 Writing a human Y chromosome (from scratch) 00:16:36 What if you could eliminate viral disease? 00:18:38 De-extinction and reinstating lost traits and genes 00:22:53 The Vertebrate Genomes Project 00:25:35 AlphaFold and other AI tools 00:37:14 CRISPR vs. Base Editing (emerging tools of genetic engineering) 00:45:27 Why multiplex editing will change the world 00:48:05 Molecular flight recorder 00:49:18 Preventing viral spillover and enhancing livestock 00:53:27 PCSK9 gene therapy for cholesterol 00:56:17 Is aging an evolved program? 01:01:08 Treating aging with a combination gene treatment 01:04:51 Does animal research help us understand human aging? 01:07:28 Organoids as a model and therapeutic 01:09:21 Could engineered transplant organs become better than the originals? 01:12:05 Embryo editing controversy 01:24:28 Gene editing for space travel 01:26:28 Can synthetic biology alleviate poverty? 01:29:55 Is in vitro fertilization and embryo selection practically similar to editing? 01:35:00 The occasional cost of brilliance and neurodivergence 01:41:33 Eradicating disease with Gene Drive 01:44:43 Technologies to solve Lyme disease 01:47:45 Personal experience with narcolepsy and creativity 01:56:29 Why George encoded his book in DNA SOCIALS: Twitter: https://twitter.com/foundmyfitness Instagram: https://instagram.com/foundmyfitness Facebook: https://www.facebook.com/foundmyfitness PODCAST: Apple Podcasts: https://podcasts.apple.com/us/podcast/foundmyfitness/id818198322 Spotify: https://open.spotify.com/show/5QjpaU0o1Q2MkVZwwG3y7d SCIENCE OF HEALTHSPAN EMAIL NEWSLETTER: Receive emailed episode notifications and regular updates on the emerging science of healthspan. https://www.foundmyfitness.com/newsletter?utm_source=youtube&utm_medium=youtube&utm_campaign=church_interview Premium subscribers of FoundMyFitness get access to a Google Presentation for the graphics in videos, earlier access, a two-times-per-month science news digest and commentary, and some kind of live online event usually every month. Learn more at: https://www.foundmyfitness.com/premium?utm_source=youtube&utm_medium=youtube&utm_campaign=church_interview. Thank you for watching! #crispr #syntheticbiology #genetics