Dr. Giles Yeo is a geneticist and obesity researcher at the University of Cambridge. He specialises in how brain and genetic factors influence appetite and body weight regulation. He’s known for communicating complex science around obesity, appetite, and nutrition in an accessible way through media, books, and public talks. In this episode, Giles and I dig into how our genes - especially those in the brain’s appetite and reward centres - shape our hunger signals, fat storage, and body fat “set‑points”. We explain why diets often fail and how to reset our appetite. Stay tuned to find out: ➡︎ Just how strongly our genes are to blame for appetite and body weight ➡︎ The specific brain region that regulates hunger and energy balance ➡︎ Whether weight loss injections are really the answer ➡︎ Why obesity is biological - not a moral failing ➡︎ The 3 numbers to remember for weight loss Connect with Dr Giles Yeo: Instagram: https://www.instagram.com/gilesyeo X: https://x.com/GilesYeo Grab Giles’ book here: https://amzn.eu/d/hoAnVLr Get my free weekly newsletter filled with easy to action health tips, interesting facts and science to fill your curiosity: https://drkaran.beehiiv.com/subscribe For more useful science for your everyday life, grab my best selling book “This Book May Save Your Life”: https://geni.us/DrKaranBook An OG Podcasts production. #DrKaran #MedicalScience #HealthEducation #HealthTips Don't miss an episode! Subscribe NOW: https://www.youtube.com/@DrKaran?sub_confirmation=1 About Dr Karan: Dr. Karan Rajan is a doctor, author, and educator dedicated to making health and medical science accessible to all. Through evidence-based analysis, he addresses topics such as gut health, brain health, and healthy lifestyle choices, while dispelling common medical myths with a touch of dark humor. His content provides reliable, research-driven insights designed to inform and empower viewers to better understand their health. Follow Dr Karan: Instagram: https://www.instagram.com/drkaranrajan/ Facebook: https://www.facebook.com/DrKaranR/ TikTok: https://www.tiktok.com/@dr.karanr X: https://twitter.com/drkaranrajan Website: https://linktr.ee/ThisisVitalInformation What Makes Us Fat? The Genetics of Appetite with Giles Yeo | Dr Karan https://www.youtube.com/@DrKaran