_In loving memory of Nolan Williams (1982-2025):_ ⁠⁠https://stan.md/3Qle2zp⁠⁠ In this Huberman Lab Essentials episode, my guest is Dr. Nolan Williams, MD, a triple board-certified psychiatrist and neurologist. We discuss cutting-edge treatments for depression and post-traumatic stress disorder (PTSD), including transcranial magnetic stimulation, neuromodulation, and psychedelic-assisted therapies. We also discuss the neurobiology and therapeutic potential of specific psychedelic compounds, including psilocybin, MDMA, ibogaine, and ayahuasca. Show notes: https://go.hubermanlab.com/KWwu7p6 Watch more Huberman Lab Essentials: https://youtube.com/playlist?list=PLPNW_gerXa4OGNy1yE-W9IX-tPu-tJa7S&si=a1_sA7rUT-fE0OM5 Huberman Lab Instagram: https://www.instagram.com/hubermanlab Threads: https://www.threads.net/@hubermanlab X: https://x.com/hubermanlab Facebook: https://www.facebook.com/hubermanlab TikTok: https://www.tiktok.com/@hubermanlab LinkedIn: https://www.linkedin.com/in/andrew-huberman Website: https://www.hubermanlab.com Newsletter: https://www.hubermanlab.com/newsletter Timestamps 00:00:00 Nolan Williams 00:00:26 Depression 00:02:51 Heart & Mind Connection, Transcranial Magnetic Stimulation (TMS) 00:05:21 TMS for Depression 00:07:52 SSRIs & Chemical imbalance, TMS, Psychedelics 00:13:51 Psilocybin, MDMA, Trauma 00:16:48 MDMA Clinical Trials & PTSD; Psilocybin & Depression 00:18:46 Psilocybin, Brain Connectivity & Depression 00:21:07 Ibogaine, Empathy; Psychedelic Breakthrough & Risk 00:27:44 Ayahuasca, Behavior Change, Prisoners 00:31:54 Stanford Accelerated Intelligent Neuromodulation Therapy (SAINT) 00:35:56 Acknowledgements #hubermanlab #science Disclaimer & Disclosures: https://www.hubermanlab.com/disclaimer