This episode is a two-for-one, and that’s because the podcast recently hit its 10-year anniversary and passed one billion downloads. To celebrate, I’ve curated some of the best of the best—some of my favorites—from more than 700 episodes over the last decade. I could not be more excited. The episode features segments from episode No. 427 "Michael Lewis — Inside the Mind of the Iconic Writer" and episode No. 487 "Dr. Martine Rothblatt — A Masterclass on Asking Better Questions and Peering Into the Future." Please enjoy! Sponsors: Shopify global commerce platform, providing tools to start, grow, market, and manage a retail business: https://shopify.com/tim (one-dollar-per-month trial period) AG1 all-in-one nutritional supplement: https://drinkag1.com/tim (1-year supply of Vitamin D [and 5 free AG1 travel packs] with your first subscription purchase.) Eight Sleep’s Pod 4 Ultra sleeping solution for dynamic cooling and heating: https://eightsleep.com/tim (save $350 on the Pod 4 Ultra) Timestamps: [00:00] Start [04:29] Notes about this supercombo format. [05:32] Enter Michael Lewis. [06:10] Why Michael quit his well-paid job to become a full-time author. [13:14] Liar’s Poker is a cautionary tale, not a how-to book. [15:32] On ambition and the metrics of success. [18:47] Maximizing self-satisfaction, optimizing the writing process, and learning to sing. [21:07] The value of having an impolite editor on your side. [24:08] On the merits of productive laziness. [28:29] How Michael determines if a project should proceed. [30:07] Michael’s billboard. [33:01] Enter Martine Rothblatt. [33:30] Martine’s appreciation for Alan Watts’ book on human identity. [35:50] Martine’s thoughts on AI-human coexistence in the movie Her. [36:47] BINA48 and realistic human simulations in media. [40:09] Martine’s role models and inspirations. [41:36] When Martine started a biotech company to save her daughter’s life. [53:00] Glaxo Wellcome’s misconceptions about Martine’s successful drug. [56:33] Martine’s interest in satellite communication systems. [1:00:49] Promoting scientific literacy and curiosity. [1:05:36] Questioning authority and Martine’s transgender journey. [1:10:44] Martine’s non-binary gender identity. [1:12:50] Key decisions in Martine’s transition. [1:13:44] The need for genetic information protection laws. [1:16:16] South American population and organ transplant research. [1:21:58] Vagus nerve manipulation for various therapies. [1:31:41] Martine’s Alzheimer’s cognitive enabler patent. [1:38:33] The Rothblatt family’s “love nights” tradition. [1:44:10] The possibility of machines experiencing love. [1:49:36] Ethical considerations for future technology. [1:53:00] Current practices future generations might view as barbaric. [1:57:58] United Therapeutics’ zero-carbon-footprint headquarters. [2:00:48] Refurbishing unusable lungs to save lives. [2:05:01] United Therapeutics’ focus on long-term COVID-19 effects. [2:07:42] Martine’s billboard. [2:08:43] Advice for finding positivity in life. [2:12:04] Parting thoughts. Tim Ferriss is one of Fast Company’s “Most Innovative Business People” and an early-stage tech investor/advisor in Uber, Facebook, Twitter, Shopify, Duolingo, Alibaba, and 50+ other companies. He is also the author of five #1 New York Times and Wall Street Journal bestsellers: The 4-Hour Workweek, The 4-Hour Body, The 4-Hour Chef, Tools of Titans and Tribe of Mentors. The Observer and other media have named him “the Oprah of audio” due to the influence of his podcast, The Tim Ferriss Show, which has exceeded 900 million downloads and been selected for “Best of Apple Podcasts” three years running. Sign up for "5-Bullet Friday" (Tim's free weekly email newsletter): https://go.tim.blog/5-bullet-friday-yt/ Follow the Tim Ferriss Podcast: https://tim.blog/podcast/ Visit the Tim Ferriss Blog: https://tim.blog/ Follow Tim Ferriss on Twitter: https://twitter.com/tferriss/ Follow Tim Ferriss on Instagram: https://www.instagram.com/timferriss/ Like Tim Ferriss on Facebook: https://www.facebook.com/TimFerriss/