Science says eating just one meal per day can improve your health. Learn more at https://highintensityhealth.com/OMAD ----- Connect with Dominic D'Agostino, PhD shares some updates about how the ketogenic diet affects metabolism and brain function. ➢ Connect with Dom: https://ketonutrition.org ➢ Ketogenic Diet, Cancer Metabolism & The Warburg Effect w/ Angela Poff, PhD: https://www.youtube.com/watch?v=uKsoKtkvChA ------------------------------------Watch Next------------------------------- ➢ Ketogenic Diet Explained w/ Jong Rho, MD: https://youtu.be/2EZ6pYOdqvg ➢ Best Berberine: http://bit.ly/2vGCgIB -----------------------------------------Lets Connect!!-------------------------------------- ➢ Facebook https://www.facebook.com/MikeMutzelMS ➢ Listen to the Audio in iTunes: https://itunes.apple.com/us/podcast/2... ➢ Instagram https://www.instagram.com/metabolic_mike --------------------------------------Key Takeaways---------------------------------- 01:38 One of Dr. D’Agostino’s early experiments lead to researchers developing and using ketones as a mitigation countermeasure to prevent oxygen toxicity seizures. 03:17 Nutritional ketosis has a stabilizing effect upon the brain. 03:54 The ketogenic diet and exogenous ketones impact many different mechanisms in synergy. Drugs impact one mechanism. 04:31 The cells of the hippocampus are selectively vulnerable to oxidative stress and energy deprivation, thus make effective study samples. 05:30 Acetyl acetate is neuroprotective, so the ketone esters developed by his lab are high in both acetyl acetate and beta hydroxybutyrate. 08:07 Clinically, the state of nutritional ketosis is defined as an elevation of blood beta hydroxybutyrate 0.5 and above or urine ketones, which measure acetyl acetate, is 15 mg/deciliter or above. 09:54 The more we subject our livers to oxidizing fats for fuel, the greater capacity we will have over time, unless we have a fatty oxidation disorder. 13:34 We may have the ability to robustly increase our capacity to make ketones, as well as break down and use ketones. 15:38 Ketone supplements, especially the ketone esters, have the capacity to be toxic if they are consumed in large quantities. 16:35 Dr. D’Agostino has tested 20 different types of ketones and ketone formulations. 17:22 Ketones have been found to be neuroprotective against high levels of oxygen, reactive oxygen species, glutamate and excitotoxicity. 21:18 The most potent anti-seizure effects found in animal models are from the elevation of both beta hydroxybutyrate and acetyl acetate. 23:52 Independent of their metabolic properties, ketone molecules have potent signaling properties. 29:38 Acetyl acetate does not have an enantiomer. Beta hydroxybutyrate does. 31:36 Exogenous ketones, when consumed as a bolus, can lower blood glucose levels via what appears to be a mechanism that is independent of insulin. 41:40 Ketones mitigate oxidative stress by enhancing mitochondrial energy production and reducing the leaking of electrons through the electron transport chain to molecular oxygen. 44:40 The activity of the enzyme, glutamic acid decarboxylase, is increased when you are in a state of nutritional ketosis and with exogenous ketones. 46:04 Exogenous ketones work through the adenosine A1 receptor. Adenosine is neuroprotective, has many different effects upon the heart and is a potent vasodilator. 46:40 Being in a state of moderate ketosis can augment brain blood flow by up to 30%. 47:18 Your brain stores more creatine when you are in ketosis. Creatine is neuroprotective, even against brain injury. 51:41 Ketosis brings the brain back to a state of balance: energetic balance, redox balance, and probably neurotransmitter balance. In ketosis, the energetic state of a cell can be preserved with less oxygen. 57:39 The ketogenic diet is being found to be effective therapy in a number of diseases.. 01:03:32 Being in a state of ketosis, combined with a state of mild calorie restriction, quiets the brain and reduces anxiety behavior (in rodent models).. Parents report that placing their child on a ketogenic style diet improves behavior. 01:06:35 Exogenous ketones can attenuate some of the rebound effect from periodic hypoglycemia, which would activate your sympathetic nervous system. 01:11:26 A ketogenic diet approach can be used to maintain and build muscle. 01:15:10 Your mitochondrial function will be better preserved if you live in a state of or go in and out of a state nutritional ketosis and do intermittent fasting a few times a week. 01:17:02 Exercise is a huge hammer, as big as nutrition, in slowing aging. 01:22:11 The ketogenic diet works for weight loss, in part, through an appetite suppressing effect. Weight loss due to ketone supplementation is from the ketone effects upon brain energy metabolism.