In this journal club episode, my guest is Dr. Peter Attia, M.D., a Stanford and Johns Hopkins-trained physician focusing on healthspan and lifespan and the host of The Drive podcast. We each present a peer-reviewed scientific paper chosen because it contains novel, interesting, and actionable data. First, we discuss a paper on how bright light exposure at sunrise and throughout the day and dark exposure at night independently improve mental health and can offset some of the major symptoms of mental health disorders such as depression and anxiety. Then, we discuss an article that explores a novel class of immunotherapy treatments to combat cancer. We also discuss some of the new data on low-calorie sweeteners and if they are safe. This episode should be of interest to listeners curious about maximizing their vitality and longevity and to anyone seeking science-supported ways to improve mental health and lifespan. Thank you to our sponsors AG1: https://drinkag1.com/huberman Eight Sleep: https://eightsleep.com/huberman BetterHelp: https://betterhelp.com/huberman Joovvv: https://joovv.com/huberman LMNT: https://drinklmnt.com/huberman Momentous: https://livemomentous.com/huberman Dr. Peter Attia Website: https://peterattiamd.com The Drive Podcast: https://peterattiamd.com/podcast Newsletter: https://peterattiamd.com/newsletter Early Medical: https://earlymedical.com X: https://twitter.com/PeterAttiaMD Instagram: https://www.instagram.com/peterattiamd Facebook: https://www.facebook.com/peterattiamd YouTube: https://www.youtube.com/c/PeterAttiaMD Journal Articles Day and night light exposure are associated with psychiatric disorders: an objective light study in greater than 85,000 people (first article discussed): https://go.nature.com/47aIZcp Early evening light mitigates sleep compromising physiological and alerting responses to subsequent late evening light: https://go.nature.com/3S84JzV Absence of Circadian Phase Resetting in Response to Bright Light Behind the Knees: https://bit.ly/3Sr4Qb1 Time spent in outdoor light is associated with mood, sleep, and circadian rhythm-related outcomes: A cross-sectional and longitudinal study in over 400,000 UK Biobank participants: https://bit.ly/3Oe376l Improved Survival with Ipilimumab in Patients with Metastatic Melanoma (second article discussed): https://bit.ly/492TmzX Understanding the Warburg Effect: The Metabolic Requirements of Cell Proliferation: https://bit.ly/3OaZr5o Screening for the Lynch Syndrome (Hereditary Nonpolyposis Colorectal Cancer): https://bit.ly/3HqgjBx Autoimmunity Correlates With Tumor Regression in Patients With Metastatic Melanoma Treated With Anti–Cytotoxic T-Lymphocyte Antigen-4: https://bit.ly/3U6G3KA Other Resources Tuo: https://www.thetuolife.com Light Meter app (Google Play): https://bit.ly/3ubAIXL Light Meter app (App Store): https://apple.co/47GJivn Carbon app: https://www.joincarbon.com Fluorescence & Mammals: https://nyti.ms/493aTYU Dr. Alia Crum: Science of Mindsets for Health & Performance: https://go.hubermanlab.com/nEZXQlCXYT Sugar Substitutes: https://bit.ly/48IJR9e The mechanisms of action for immune checkpoint inhibitors: https://bit.ly/3SqTi7v Disclaimer: https://www.hubermanlab.com/disclaimer