Science says eating just one meal per day can improve your health. Learn more at https://highintensityhealth.com/OMAD ----- Angela Poff PhD discusses the metabolic origins of cancer and potential anticancer effects of ketones.* ➢ Get in touch w/ Angela -http://health.usf.edu/medicine/mpp/research-staff.htm https://www.facebook.com/angelapoffphd http://www.ketonutrition.org *Disclaimer: - The information, comments, and opinions expressed in this video are those of the speaker based on their own clinical experience and interpretation of the literature and for educational purposes only -These statements have not been evaluated by the US Food and Drug Administration. The information presented herein is not intended to diagnose, treat, cure , or prevent any disease. High Intensity Health encourages you to consult with your doctor before adjusting your health care. --------------------------------------Lets Connect---------------------------------- ➢ Facebook https://www.facebook.com/MikeMutzelMS ➢ Listen to the Audio in iTunes: http://highintensityhealth.com/itunes https://itunes.apple.com/us/podcast/174-angela-poff-phd-cancer/id910048041?i=1000380322226&mt=2 ➢ Instagram https://www.instagram.com/metabolic_mike --------------------------------------Key Takeaways---------------------------------- 02:08 Metabolism and Cancer: There are certain hallmarks of cancer. Cancer cells need to keep dividing. 02:54 The Warburg Effect: Almost 100 years ago Otto Warburg showed that cancer cells don’t undergo normal energy metabolism.   04:36 Oxygen and the Warburg Effect: This process occurs whether oxygen is present or not. In normal cells, we utilize lactate fermentation when oxygen is limited. Cancer cells do this even when oxygen is present. 05:42 Mitochondrial Dysfunction: There is widespread mitochondrial dysfunction in cancer. 09:04 Cell Division: Every time your cell divides, it has to copy its DNA. Mistakes will be made, but we have repair mechanisms that survey and fix mutations. 09:47 Lactic Acid and Cancer: The cancer field views aerobic glycolysis, or the Warburg Effect, as a beneficial adaptation of tumors. 12:45 Fat Consumption and Cancer: Fatty acids and ketone bodies are converted into acetyl-coA to enter the metabolic pathways at the level of the Krebs cycle. 14:03 Hypoxia-inducible factor 1-alpha (HIF1 Alpha): Tumors grow under chaotic abnormal signaling properties. In order to grow past a certain size, the tumor needs to make its own new blood vessels. The chaos makes the blood vessel network abnormal and inadequate. 16:30 Hyperbaric Oxygen Therapy: At sea level, we breathe 20% oxygen. In HBOT, oxygen intake is increased to 100%. 19:02 Oxygen Free Radical Production: In some parts of the tumor there may be no oxygen and parts of the tumor may die. 20:10 Radiation Therapy and Oxygen: Radiation causes the formation of free radicals. 21:11 Oxygen Therapies for Treatment and Prevention: 22:38 Mitochondria Membranes: Healthy functioning mitochondria act as tumor suppressors. By preserving mitochondrial membrane, in turn helps to preserve mitochondrial function.  A well formulated ketogenic diet helps with cell membrane integrity. 25:21 Insulin Signaling and Cancer: Insulin is a potent growth factor in cancers. Many cancer types upregulate insulin receptors and IGF receptors. Insulin promotes tumor growth. 26:20 Ketogenic Diet and Glucose: We don’t always get a remarkable drop in circulating blood glucose. 27:33 Pro-Oxidant Therapies:  Oxidative stress is a double edged sword for cancer. Cancer cells at a basal level operate under more free radicals and more oxidative stress than our healthy tissues. 31:11 The Effects of Ketones: Ketones have anticancer effects. They have very important signaling and functional roles in our cells that have nothing to do with their role as energy metabolites. 33:09 Inflammation: It is a huge component in cancer origination and progression. Ketosis is anti-inflammatory. Beta hydroxybutyrate inhibits the assembly of the NLRP3 inflammasome that is activated during cancer, ageing and many chronic illnesses that incite inflammation. 35:56 Ketones and the Alterations in Oxidative Stress: Ketone metabolism decreases free radical production, reducing oxidative stress and increasing antioxidant capacity. 37:17 Ketones and Glycolysis:  Some data suggests that ketones can inhibit glycolysis, an important pathway in cancer. 41:31 Restoring Anti-Tumor Immunity: The ketogenic diet restores anti-tumor immunity. 44:14 Ketogenic Cancer Benefits: There is not a lot of human data on the ketogenic diet and cancer. There are 12 clinical trials registered now. 46:44 Dr. Poff’s Morning Routine: She awakens early and spends quality time with her husband and pets.