Science says eating just one meal per day can improve your health. Learn more at https://highintensityhealth.com/OMAD ----- This could be one of the most important discussions we've had up to now. We discuss a rather complex topic: immunometabolism. This emerging field is the intersection between metabolism and immunity. Understanding it is key to unraveling how metabolic therapies (ketogenic diet) and fasting affect the whole body; including the immune system. ➢This episode is brought to you by MYOXCIENCE Nutrition https://www.amazon.com/myoxcience New Keto + MCT MicroDose: https://amzn.to/2MSJVuf ➢Connect with Alena: https://www.ohsu.edu/providers/alena-guggenheim/44D98531F4B4E53A771C5A8204074F7E Links to Top Resources Discussed: ➢ Perfect Keto, the makers of high-quality exogenous ketones and MCT oil products. *Save over 20% OFF: https://www.perfectketo.com/HIH **We love their new Salted Carmel product Joovv Light: https://lddy.no/3pck Save w/ code: HIH Oura Ring: https://ouraring.com/ Save $50 w/ code HIH -----------------------------------------Lets Connect-------------------------------------- ➢ iTunes Podcast: https://highintensityhealth.com/itunes ➢ Instagram https://www.instagram.com/metabolic_mike ➢ Facebook https://www.facebook.com/MikeMutzelMS -------------------------------------- VIDEO GEAR------------------------------------------------- Best Vlog & FB Live Stabilizer: https://amzn.to/2wcoJXZ Nice HD Camera Canon 6D Mark II https://amzn.to/2JyxrG5 Interview Cam C100 ii: https://amzn.to/2EC5NE8 Best Lens Ever: https://amzn.to/2IJ9WZC Vlog lens: Canon EF-S 17-55mm f/2.8 IS: https://amzn.to/2IGlfSo Dope Lens - Canon 85mm f/1.4L IS: https://amzn.to/2IFRG3h Good Audio: Rode VMPRPLUS Videomic Pro: https://amzn.to/2v9W9cm -------------------------------------- Key Timestamps---------------------------------- 04:46 Your immune system can accidently attack the body or it may miss something that has gone wrong, like cancer growth. 05:12 The immune system, via inflammation, plays a role in all sorts of diseases and chronic diseases, like diabetes and heart disease. 05:44 Different parts of your immune system have different preferred food sources. 07:07 Our immune system has peacekeepers, T-regulatory cells and B-regulatory cells. The depletion of Treg and Breg cells is implicated in every autoimmune disease. 07:50 Everything the immune system does is metabolically costly and takes money, in the form of ATP. 09:30 The peacekeepers prefer fatty acid metabolism. 11:13 High CRP is not your body responding to any specific thing. 14:00 Metformin is being researched of its use in treating Lupus. 15:39 Mitochondria are responsible for metabolism, making energy in your cells. 16:57 Mitochondrial dysfunction is present in inflammatory disorders. 17:35 Our mitochondria are symbionts that probably came from bacteria and are vulnerable to some of the same things that damage bacteria, like antibiotics and pesticides. 19:16 You can only poison your mitochondria so much. 20:20 The cheapest and most effective mitochondrial nutrient is N-acetylcysteine. 21:46 Berberine is similar metabolically to Metformin, but there is not the body of evidence that there is with diabetic research. 24:58 If you don’t have enough mTOR, you will not get new cell building and you go into breakdown phase. 27:53 Beta hydroxybutyrate feeds your peacekeeper T-regs. 29:20 Macrophages are sentinels, to sense the general environment. They sense microbes, metabolism, nutrients, temperature and can probably sense light. 31:33 The macrophages inside visceral fat tend to be m2 and cause metabolic disturbance, increasing levels of inflammation. 36:18 T-reg signaling is dependent upon vitamin D. 38:04 Labs for immune, metabolic or hormone health are snapshots, especially with diurnal hormones. 42:01 The first thing you can do to improve your metabolic health is to follow the Okinawan Hara Hachi Bu. Eat until you are 80% full. 43:39 You cannot listen to your satiety signals if you eat quickly. 46:56 Dr. Guggenheim’s morning routine centers around her kids. First thing, she drinks something warm. 49:45 Dr. Guggenheim’s desert island nutrient is curcumin. 50:42 Dr. Guggenheim’s elevator pitch is a recommendation for a policy change to discontinue food subsidies.