In this episode my guest is Satchin Panda, PhD, professor and director of the Regulatory Biology Laboratories at the Salk Institute for Biological Studies. We discuss his lab’s discovery that time-restricted eating (TRE), also known as intermittent fasting, has beneficial effects on metabolic health and longevity. Dr. Panda explains how TRE, and longer fasts as well, can positively impact obesity, diabetes, cardiovascular health, age-related chronic diseases and improve mood and cognitive performance. He also describes how the timing of eating, light exposure and exercise that roughly 50% of people engage in negatively affects their health, and he explains how simple adjustments to these factors can improve their subjective sense of wellbeing and biomarkers of cardiovascular function, glucose regulation and metabolism. We discuss how our circadian behaviors, which include patterns of eating, sleeping and socializing, have an enormous impact on our biology, mood and health, and how confining calorie consumption to a semi-regular daily window can enhance physical health, mental health and longevity. Thank you to our sponsors AG1 (Athletic Greens): https://athleticgreens.com/huberman HVMN: https://hvmn.com/huberman Eight Sleep: https://eightsleep.com/huberman Thesis: https://takethesis.com/huberman Momentous: https://www.livemomentous.com/huberman InsideTracker: https://www.insidetracker.com/huberman Social & Website Instagram: https://www.instagram.com/hubermanlab Twitter: https://twitter.com/hubermanlab Facebook: https://www.facebook.com/hubermanlab LinkedIn: https://www.linkedin.com/in/andrew-huberman Website: https://hubermanlab.com Newsletter: https://hubermanlab.com/neural-network Dr. Satchin Panda Salk Institute: https://www.salk.edu/scientist/satchidananda-panda Panda Lab: https://panda.salk.edu Publications: https://panda.salk.edu/publications Support Dr. Panda’s Research: https://panda.salk.edu/giving Twitter: https://twitter.com/SatchinPanda Instagram: https://www.instagram.com/satchin.panda Other Resources My Circadian Clock app: https://mycircadianclock.org Ontime Health app: https://getontimehealth.com Articles Revival of light signalling in the postmortem mouse and human retina: https://go.nature.com/3ZWnGro Circadian alignment of early onset caloric restriction promotes longevity in male C57BL/6J mice: https://bit.ly/3ywruE3 Time-restricted eating with or without low-carbohydrate diet reduces visceral fat and improves metabolic syndrome: A randomized trial: http://bit.ly/3LeBdqg Embers of society: Firelight talk among the Ju/’hoansi Bushmen: https://bit.ly/3l65LzK Circadian Entrainment to the Natural Light-Dark Cycle across Seasons and the Weekend: http://bit.ly/3LhsWlm Feasibility of time-restricted eating and impacts on cardiometabolic health in 24-h shift workers: The Healthy Heroes randomized control trial: http://bit.ly/3FeR1FC Access to Electric Light Is Associated with Shorter Sleep Duration in a Traditionally Hunter-Gatherer Community: https://bit.ly/3LivSyj Daily Eating Patterns and Their Impact on Health and Disease: https://bit.ly/3YGIHW6 Books The Circadian Code: https://amzn.to/3FixpAv The Circadian Diabetes Code: https://amzn.to/3FiU7Zm Disclaimer: https://hubermanlab.com/disclaimer