Jacob Kimmel thinks he can find the transcription factors to reverse aging. We do a deep dive on why this might be plausible and why evolution hasn’t already optimized for longevity. We also talk about why drug discovery has been getting exponentially harder, and what a new platform for biological understanding to speed up progress would look like. As a bonus, we get into the nitty gritty of gene delivery and Jacob’s controversial takes on CAR-T cells. For full disclosure, I am an angel investor in NewLimit. This did not impact my decision to interview Jacob, nor the questions I asked him. 𝐄𝐏𝐈𝐒𝐎𝐃𝐄 𝐋𝐈𝐍𝐊𝐒 * Transcript: https://www.dwarkesh.com/p/jacob-kimmel * Apple Podcasts: https://podcasts.apple.com/us/podcast/why-evolution-designed-us-to-die-fast-how-we-can-change/id1516093381?i=1000722975425 * Spotify: https://open.spotify.com/episode/3xUwUYLpjGI3bxsEM114jq?si=mo4FBuI4RoG42PUYYCFUDw 𝐒𝐏𝐎𝐍𝐒𝐎𝐑𝐒 * Hudson River Trading uses deep learning to tackle one of the world's most complex systems: global capital allocation. They have a massive in-house GPU cluster, and they’re constantly adding new racks of B200s to ensure their researchers are never constrained by compute. Explore opportunities at https://hudsonrivertrading.com/dwarkesh * Google’s Gemini CLI turns ideas into working applications FAST, no coding required. It built a complete podcast post-production tool in 10 minutes, including fully functional backend logic, and the entire build used less than 10% of Gemini’s session context. Check it out on Github now: https://goo.gle/4mw9BNg To sponsor a future episode, visit https://www.dwarkesh.com/advertise 𝐓𝐈𝐌𝐄𝐒𝐓𝐀𝐌𝐏𝐒