High levels of stress, specifically toxic or unmitigated stress, can accelerate cellular aging, while optimal stress can be beneficial.

“I mean I study chronic stress and how it accelerate cell aging and I can tell you there's so much variance between people people are so different so among caregivers some of them look as biologically young or younger than our controls people with no identifiable big tough situation in their life”

Exercise can mitigate the risks of high protein intake by directing growth factors like IGF-1 towards muscle and brain tissue instead of towards tissues where they might promote cancer.

“exercise modulates growth factors like igf-1 diverting them towards muscle and brain tissue where they support repair and growth while potentially mitigating their procancer effects in other tissues”