Science says eating just one meal per day can improve your health. Learn more at https://highintensityhealth.com/OMAD ----- Welcome to episode #164 with Jong M. Rho, MD. We explore some of the latest research findings about how the ketogenic diet improves our health. ➢Enroll in our free Keto Classes: https://courses.highintensityhealth.com/ ➢Join our Keto Member Portal: https://www.patreon.com/highintensityhealth ➢ Connect with Dr. Rho: http://research4kids.ucalgary.ca/profiles/jong-m-rho ➢ http://www.ketoconnect.org/ ➢ Listen in iTunes https://itunes.apple.com/us/podcast/164-jong-rho-md-how-ketones/id910048041?i=1000377932826&mt=2 ➢ Read the show notes: http://highintensityhealth.com/164 -----------------------------------------Lets Connect-------------------------------------- ➢ Facebook https://www.facebook.com/MikeMutzelMS ➢ Listen to the Audio in iTunes: http://highintensityhealth.com/itunes ➢ Instagram https://www.instagram.com/metabolic_mike --------------------------------------Key Takeaways---------------------------------- The science supporting the health benefits of a low-carb, high-fat diet continues to get stronger. From reduced inflammation to improved fat-burning mitochondrial function to a changed microbiome, the evidence is there. Leading pediatric neurologist in the space, Jong Rho, MD, came by to discuss the details His laboratory continues to publish new research about how ketogenic diets affect the brain. Here's what he covered: -The ketogenic diet and epilepsy -How ketones affect whole-body metabolism and inflammation -Ketogenic diet applications for autism, brain cancer, Alzheimer's disease and brain injury -Dispelling myths about carbs and brain health Hope you enjoy this one! Mike 01:30 Interest in the Ketogenic Diet: Interest in the diet stems from its efficacy against seizures in those who don’t respond to anti-seizure drugs. 02:48 Attributes of Beta Hydroxybutyrate: Beta hydroxybutyrate is a simple metabolite that is the result of fatty acid oxidation, used as an energy molecule. During brain development it is used as a carbon skeleton for creating membranes around cells. It has anti-inflammatory properties, . Beta hydroxy is poised within the metabolism and immune system. Beta hydroxy is also an epigenetic modulator. It is a histone deacetylase inhibitor, which can alter the way genes are ultimately expressed in our bodies. 04:01 Cancer Research: Cancer researchers have pioneered the H-stack inhibitors for cancer. The results of this research may be applicable to other neurological diseases, such as epilepsy. H-stack inhibitors are expensive and fraught with significant side effects. 04:51 Ketogenic Diet and the Disease State: The ketogenic diet renders a homeostatic effect. 05:36 Impacts upon Metabolism: The diet has been shown to return metabolism to normal, rather than revved or sluggish. The diet increases energy reserve, mostly through ketones. Too much glucose is not good for cellular function and the ketogenic diet tends to reduce the overall glucose burden and keep it on a more even keel, positively impacting brain function. 07:02 Impacts of Fatty Acids: 08:57 Brain Development and Ketones: 10:46 Reducing Inflammation: The NLRP3 inflammasome is the best example of reducing inflammation. 12:32 Ketones and the Mitochondria: 15:46 Carbohydrate Restriction: 17:20 Diabetic Ketoacidosis: More ketones are not always better. 18:39 Mitochondria Cell Death: Mitochondria are responsible for more than producing ATP. 21:56 Superoxide Dismutase Upregulation: The ketogenic diet reduces free radical modulation within the mitochondria and oxidative stress. Superoxide dismutase is necessary to rid us of bad free radical players. If you don’t have enough, you experience more damage. 23:01 “Fat is Bad for You”: We have been told for decades that fat is bad for us, so we made up for calories lost with increased carbohydrate intake. 25:10 Ketogenic Diet and Your Microbiome: The human gut microbiome is being investigated for its effects upon gut function and other organ systems, most notably the brain. 27:47 Homeostasis: Diseases produce shifts. Returning to normal can be done with diet. There are measurable significant clinical benefits by just changing the diet. 28:25 The Big Picture: There are many complicated processes that take compounds and modify them. We are only scratching the surface. It requires a systems biology approach and needs to be seen in a big data way. In epilepsy, despite decades and billions of dollars invested in drug development, the efficacy rates of anti-seizure control have not changed. 32:18 Diet Response: Some people do not respond to the diet and others are super-responders. ve created a health problem throughout the world.