Today's show is brought to you by Ned, the makers of a Biodynamically grown Hemp Oil that's amazing for sleep, stress and more https://helloned.com/hih15 Try NED to deepen your sleep with 1 mL of this CBD liquid under your under tongue~ 15 mins prior to bed, it's is a game changer! //Today's Show // Eleanor Rogan, PhD has been studying chemical carcinogens for over 30 years. Today she explores how improperly metabolized estrogens can cause cancer; specifically when they're metabolized to the Catechol estrogen quinone. -------------Sleep & Camera Tools You NEED!----------------------- Best Sleep Mask: http://bit.ly/2AIVbDV Blue Blocking Glasses: http://bit.ly/blueblox Gravity Blanket (use code HIH10 to save): http://bit.ly/cooling-gravity-blanket A Metabolism Book Should Have:https://amzn.to/2jUiAh5 Best Mouth Tape (Nexcare): https://amzn.to/31qJayh Red Headlamp (wear this at night around your house): https://amzn.to/2YzMGtw Breath Right Strips: https://amzn.to/31t5VSl Best iPhone Stabilizer: https://amzn.to/2IuCFFw Sony Vlog Cam: https://amzn.to/2DhRV4j My Interview Camera C100 ii: https://amzn.to/2EC5NE8 Vlog lens: Canon EF-S 17-55mm f/2.8 IS: https://amzn.to/2IGlfSo Good Audio: Rode VMPRPLUS Videomic Pro: https://amzn.to/2v9W9cm -----------------------------------------Show Notes-------------------------------------- 01:34 In Nebraska, fracking is an issue as is the Keystone Pipeline. A spill would likely go into the Ogallala aquifer which provides water to multiple states. 06:18 Estrone is E1. Estradiol is E2. They convert back and forth. 06:55 Catechol estrogens can be methylated. 07:18 Catechol estrogens are an endogenous carcinogen. 08:32 P450 1B1 is dangerous in the number 4 position in the molecule. It creates a quinone and is highly reactive with DNA. 10:40 A study revealed that women with ovarian cancer have higher levels of estrogen DNA adducts than women who do not have ovarian cancer. 11:03 They looked at the polymorphic variations in 2 enzymes. One was a variant that made cytokine P450 1B1 more active. The other was a variant that made catechol-o-methyltransferase, a protective enzyme, less active. Women with particular varients were 3 times more likely to have ovarian cancer. Those other varients were six times more likely to have ovarian cancer. 13:27 When our COMT is functioning normally, we make the catechol estrogen and put a methyl group on it. It cannot from a quinone. Lower levels of quinones means you have lower levels of adducts. 13:50 If your catechol-o-methyltransferase is not working well, your catechol estrogen can go on to become a quinone and react with DNA. 16:18 Dopamine is the only other molecule that goes through this kind of metabolism; however, it is pH dependent. 18:03 It would cost a few $100,000 to determine if researching dopamine quinones in Parkinson’s was the right track for something useful. Funding is not available. 19:25 Dopamine quinones make analogous DNA adducts. 20:36 Adducts are analogous to taking a step off the DNA ladder. 27:02 Men with prostate cancer have high levels of estrogen DNA adducts. It may be that prostate cancer is initiated by estrogens and promoted by testosterone. 32:22 Studies of HRT show evidence is that the problem is not with the estrogen, but with the synthetic progestin. 35:25 Dr. Rogan’s research with sulforaphane showed it not to be as effective as it was hoped. 36:08 A study of resveratrol and n-acetylcystine taken twice a day, showed that after 3 months, adduct levels were lowered significantly statistically. 43:20 Dr. Rogan is studying Fuch’s eye dystrophy. These cells make many estrogen DNA adducts. 48:46 The formation of estrogen adducts may be a fundamental mechanism of disease. It is probably involved in a variety of things besides cancer. 54:57 Promising research on estrogen carcinogenesis is not funded/supported. 01:00:22 Initiation of cancer by estrogens does not require the estrogen receptor.