Sign up to receive Peter's email newsletter: https://bit.ly/4c602k2 Original release date: 12/17/18 In this episode, Dr. Rudy Leibel, an expert in Clinical Molecular Genetics and Genomics at Columbia University, discusses his role in the remarkable scientific story of discovering leptin. He also gets into the genetics of obesity, as well as a broader discussion of the causes and effects of obesity, energy expenditure, and metabolism. We discuss: -Rudy’s background, interest in obesity, and trying to understand the role and impact of adipose tissue [4:15]; -Finding the first evidence of leptin by studying obese mice [23:30]; -Zucker rats, and the push/pull theories of obesity [34:45]; -A breakthrough in obesity research, and closing in on leptin [45:45]; -Understanding leptin in humans [1:03:30]; -What Prader–Willi syndrome teaches us about body weight regulation [1:09:45]; -Leptin and the broad condition of obesity, metabolic consequences of weight reduction, and Peter’s self-experiments [1:18:00]; -How is appetite being regulated? [1:29:45]; -Are there epigenetic consequences of being obese? [1:37:00]; -What makes low-carb diets so effective at obesity reduction? [1:46:15]; -What did Rudy believe 10 years ago that he no longer believes to be true? [1:55:15]; -Rudy’s dream study of the FTO gene [1:57:15]; -What the hell does insulin resistance actually mean? [2:08:30]; and -More. Show notes page: https://peterattiamd.com/rudyleibel/ About: The Peter Attia Drive is a weekly, ultra-deep-dive podcast focusing on maximizing health, longevity, critical thinking…and a few other things. With over 10 million episodes downloaded, it features topics including fasting, ketosis, Alzheimer’s disease, cancer, mental health, and much more. Peter is the founder of Attia Medical, PC, a medical practice with offices in San Diego and New York City, focusing on the applied science of longevity. The practice applies nutritional biochemistry, exercise physiology, sleep physiology, techniques to increase distress tolerance, lipidology, pharmacology, and four-system endocrinology to increase lifespan (delaying the onset of chronic disease), while simultaneously improving healthspan (quality of life). Learn more: https://peterattiamd.com/ Subscribe to receive exclusive subscriber-only content: https://peterattiamd.com/subscribe/ Sign up to receive Peter's email newsletter: https://peterattiamd.com/newsletter/ Connect with Peter on: Facebook: http://bit.ly/PeterAttiaMDFB Twitter: http://bit.ly/PeterAttiaMDTW Instagram: http://bit.ly/PeterAttiaMDIG Subscribe to The Drive: Apple Podcast: http://bit.ly/TheDriveApplePodcasts Overcast: http://bit.ly/TheDriveOvercast Spotify: http://bit.ly/TheDriveSpotify Google Play: http://bit.ly/TheDriveGooglePlay