Sign up to receive Peter's email newsletter: https://bit.ly/4c602k2 Original release date: 1/7/19 In this episode, Nir Barzilai, director of the Institute for Aging Research and expert in the genetics of longevity, discusses the evidence that metformin and rapamycin have anti-aging properties and how his TAME study aims to support this hypothesis in humans. Additionally, he describes the role of genetics in lifespan/healthspan and how it might affect important pathways such as IGF and insulin sensitivity. We discuss: -Nir’s background and interest in aging and endocrinology [3:30]; -History of metformin, and understanding the mechanism [11:15]; -Attempting to define insulin resistance [21:15]; -Metformin as a possible anti-aging drug [48:45]; -The TAME trial: Targeting Aging with metformin [57:45]; -Why Nir believes metformin can slow aging [1:16:30]; -The genetic gift of centenarians [1:28:00]; -IGF/GH and its impact on aging and chronic diseases [1:34:15]; -Genetics/epigenetics of centenarians, gene sequencing, CETP-VV, Lp(a) [1:49:15]; -Should you be taking HGH? [2:05:30]; -NAD and NAD precursors (NR and NMN) [2:30:00]; -Parting thoughts on metformin [2:36:15]; -Possible blind spots in Nir and Peter’s thinking? [2:43:00]; and -More. Show notes page: https://peterattiamd.com/nirbarzilai/ About: The Peter Attia Drive is a weekly, ultra-deep-dive podcast focusing on maximizing health, longevity, critical thinking…and a few other things. With over 10 million episodes downloaded, it features topics including fasting, ketosis, Alzheimer’s disease, cancer, mental health, and much more. Peter is the founder of Attia Medical, PC, a medical practice with offices in San Diego and New York City, focusing on the applied science of longevity. The practice applies nutritional biochemistry, exercise physiology, sleep physiology, techniques to increase distress tolerance, lipidology, pharmacology, and four-system endocrinology to increase lifespan (delaying the onset of chronic disease), while simultaneously improving healthspan (quality of life). Learn more: https://peterattiamd.com/ Subscribe to receive exclusive subscriber-only content: https://peterattiamd.com/subscribe/ Sign up to receive Peter's email newsletter: https://peterattiamd.com/newsletter/ Connect with Peter on: Facebook: http://bit.ly/PeterAttiaMDFB Twitter: http://bit.ly/PeterAttiaMDTW Instagram: http://bit.ly/PeterAttiaMDIG Subscribe to The Drive: Apple Podcast: http://bit.ly/TheDriveApplePodcasts Overcast: http://bit.ly/TheDriveOvercast Spotify: http://bit.ly/TheDriveSpotify Google Play: http://bit.ly/TheDriveGooglePlay