Metabolic rate remains stable from age 20 to 60 and the subsequent decline is primarily caused by reduced physical activity and loss of lean mass.

“from about age 20 till about age 60 is completely stable in this large cohort of people. And then after age 60 it starts to slowly decline. But it's less than 1% decline per year. And it's also by the way completely explained by the fact that people just become less active and have less lean mass as”

Human metabolism between the ages of 20 and 60 remains stable when the effects of excess body fat are removed.

“It turns out that when you remove the effect of excess body fat, our hard wiring for metabolism between the age of 20 and 60 is rock solid, flat as an ocean on a calm day. does not change.”

Cancer is primarily a metabolic disease caused by mitochondrial respiratory dysfunction rather than primarily a genetic disease.

“is cancer primarily a metabolic disease meaning a disease whose origin arrives in the mitochondria or in the metabolic machinery of the cell or is it primarily a genetic disease where sometimes you will and sometimes you won't sustain mitochondrial damage”

Hyperinsulinemia is a fundamental piece of the cancer puzzle that ties together obesity and cancer cell proliferation.

“in my book insulin is sort of the explanation which ties it all together which obviously not all cancers are caused by insulin and you know insulin's role according to some scientists is only indirect it causes the obesity and the obesity causes other hormonal changes in inflammation but but one way”