You might think Alzheimer's starts in your 70s. Dr. David Perlmutter explains why it begins decades earlier, and how the p-tau 217 blood test flags risk long before symptoms appear. Gary Brecka and Dr. Perlmutter break down microglia, insulin resistance, pre-diabetes, APOE4, homocysteine, vitamin D, creatine and sleep, plus what the POINTER study showed about cognitive decline in metabolically compromised adults. CLICK HERE TO BECOME GARY’S VIP!: https://bit.ly/4ai0Xwg Get Dr. David Perlmutter’s book, “Brain Defenders”: https://bit.ly/4xvoYtY Listen to Dr. David Perlmutter on all your favorite platforms! YouTube: https://bit.ly/46rZjan Spotify: https://bit.ly/4dxPdZl Apple Podcasts: https://bit.ly/4dBz19u Connect with Dr. David Perlmutter Website: https://bit.ly/4yEhBBk YouTube: https://bit.ly/46rZjan Instagram: https://bit.ly/3VgElZH Facebook: https://bit.ly/4xvTC6v TikTok: https://bit.ly/4xXDcEM X: https://bit.ly/4xxJdal LinkedIn: https://bit.ly/4yfpNIF Thank you to our partners A-GAME: “ULTIMATE15” FOR 15% OFF: http://bit.ly/4kek1ij AION: “ULTIMATE10” FOR 10% OFF: https://bit.ly/4h6KHAD AIRES: “ULTIMATE20” FOR 20% OFF: https://bit.ly/4a3Duze BAJA GOLD: “ULTIMATE10” FOR 10% OFF: https://bit.ly/3WSBqUa BODYHEALTH: “ULTIMATE20” FOR 20% OFF: http://bit.ly/4e5IjsV COLD LIFE: THE ULTIMATE HUMAN PLUNGE: https://bit.ly/4eULUKp CYMBIOTIKA: “BRECKACYM30” FOR 30% OFF: https://bit.ly/4tjyluP GENETIC METHYLATION TEST (UK ONLY): https://bit.ly/48QJJrk GENETIC TEST (USA ONLY): https://bit.ly/3Yg1Uk9 GOPUFF: GET YOUR FAVORITE SNACK!: https://bit.ly/4obIFDC H2TABS: “ULTIMATE10” FOR 10% OFF: https://bit.ly/4hMNdgg HEALF: 10% OFF YOUR ORDER: https://bit.ly/41HJg6S PEPTUAL: “TUH10” FOR 10% OFF: https://bit.ly/4mKxgcn SNOOZE: LET’S GET TO SLEEP!: https://bit.ly/4pt1T6V WHOOP: JOIN & GET 1 FREE MONTH!: https://bit.ly/3VQ0nzW Watch the “Ultimate Human Podcast” every Tuesday & Thursday at 9AM EST: YouTube: https://bit.ly/3RPQYX8 Podcasts: https://bit.ly/3RQftU0 Connect with Gary Brecka Instagram: https://bit.ly/3RPpnFs TikTok: https://bit.ly/4coJ8fo X: https://bit.ly/3Opc8tf Facebook: https://bit.ly/464VA1H LinkedIn: https://bit.ly/4hH7Ri2 Website: https://bit.ly/4eLDbdU Merch: https://bit.ly/4aBpOM1 Newsletter: https://bit.ly/47ejrws Ask Gary: https://bit.ly/3PEAJuG Timestamps 00:00 – Intro of Show 07:02 – Pre-diabetes & "pre-Alzheimer's" 15:26 – Microglia: brain defenders vs. destroyers 27:30 – Exercise as brain medicine 41:33 – Lifestyle intervention study (Tanzi/Ornish) 44:36 – The POINTER Study 50:29 – Beta-amyloid drugs: risks vs. benefits 1:07:26 – Vitamin D & brain health 1:22:26 – Red light & mitochondrial therapies 1:30:11 – Isolation & brain health 1:35:51 – "What is an Ultimate Human?" Disclaimer: This podcast is for informational purposes only and does not provide medical advice. It is not intended for diagnosing or treating any health condition. Always consult a licensed healthcare professional before making health or wellness decisions. Gary Brecka is the owner of Ultimate Human, LLC which operates The Ultimate Human podcast and promotes certain third-party products used by Gary Brecka in his personal health and wellness protocols and daily life and for which Ultimate Human LLC and / or Gary Brecka directly or indirectly holds an economic interest or receives compensation. Accordingly, statements made by Gary Brecka and others (including on The Ultimate Human podcast) may be considered promotional in nature.