What is the world made of? How does it behave? These questions, aimed at the most basic level of reality, are the subject of fundamental physics. What counts as fundamental is somewhat contestable, but it includes our best understanding of matter and energy, space and time, and dynamical laws, as well as complex emergent structures and the sweep of the cosmos. Few people are better positioned to talk about fundamental physics than Frank Wilczek, a Nobel Laureate who has made significant contributions to our understanding of the strong interactions, dark matter, black holes, and condensed matter, as well as proposing the existence of time crystals. We talk about what we currently know about fundamental physics, but also the directions in which it is heading, for better and for worse. Frank Wilczek received his Ph.D. in physics from Princeton University. He is currently the Herman Feshbach professor of physics at the MIT; Founding Director of the T. D. Lee Institute and Chief Scientist at Wilczek Quantum Center, Shanghai Jiao Tong University; Distinguished Professor at Arizona State University; and Professor at Stockholm University. Among his numerous awards are the MacArthur Fellowship, the Nobel Prize in Physics (2004, for asymptotic freedom), membership in the National Academy of Sciences and the American Academy of Arts and Sciences. He is the author of numerous books, most recently Fundamentals: Ten Keys to Reality. Blog post with audio player, show notes, and transcript: https://www.preposterousuniverse.com/podcast/2021/01/18/130-frank-wilczek-on-the-present-and-future-of-fundamental-physics/ Patreon: https://www.patreon.com/seanmcarroll Mindscape Podcast playlist: https://www.youtube.com/playlist?list=PLrxfgDEc2NxY_fRExpDXr87tzRbPCaA5x #podcast #ideas #science #philosophy #culture