Dr. Rhonda Patrick speaks with Dr. Satchidananda Panda, a professor at the Salk Institute for Biological Studies in La Jolla, California. Satchin's work deals specifically with the timing of food and it's relationship with our biological clocks governed by circadian rhythm and also the circadian rhythm in general. In this video we discuss... •The fascinating history of experimentation that ultimately elucidated the location for the region of the brain necessary for a properly timed sleep-wake cycles. • The relationship between our body's "master clock" and it's many peripheral clocks. • Why infants sleep so intermittently, instead of resting for a longer, sustained duration like healthy young adults... and why this sustained rest also goes haywire in the elderly. • The fascinating work Dr. Panda took part in that lead to the discovery of a specialized light receptor in the eye that sets circadian rhythms and is known as melanopsin. • The important relationship between the relatively light insensitive melanopsin, which requires around 1,000 lux of light to be fully activated, and its control of the circadian clock by means of activation of the suprachiasmatic nucleus and suppression of melatonin. • The effects light exposure seems to have on next-day cortisol, a glucocorticoid hormone that regulates around 10-20% of the human protein-encoding genome. • The clever experimental design by which Dr. Panda and his colleagues discovered that certain circadian rhythms, especially of the liver, are entrained by when we eat, instead of how much light we get. This underlines the fact that, when managing are circadian rhythm, both elements are important! • One of the more surprising effects of time-restricted feeding in mice eating a so-called healthy diet: increases in muscle mass and even endurance in some cases. EPISODE LINKS: Show notes and transcript: https://www.foundmyfitness.com/episodes/satchin-panda?utm_source=youtube&utm_medium=youtube&utm_campaign=panda_interview Dr. Satchin Panda on Twitter: https://twitter.com/satchinpanda Dr. Satchin Panda's Website: http://www.mycircadianclock.org/ You can try out time-restricted feeding and contribute to human research! Commit to 14 weeks and download Dr. Panda's mobile app to get started. Learn more: http://mycircadianclock.org/participant PODCAST INFO: Email: https://www.foundmyfitness.com/newsletter?utm_source=youtube&utm_medium=youtube&utm_campaign=panda_interview Apple Podcasts: https://podcasts.apple.com/us/podcast/foundmyfitness/id818198322?i=1000532219811 Spotify: https://open.spotify.com/episode/2sW7Say3wMbBUg34gW0X4s?si=Pk53_kieRF-AxH1l6TIzkg&nd=1 Full interview playlist: https://www.youtube.com/playlist?list=PLJEEAVzHu9KzgkQbe2Thh35VU-HCiId_s Clips playlist: https://www.youtube.com/playlist?list=PLrGxo-5Uw8gI9-1IStYEvNxVukKxZBlmi Chapters 00:00:00 - Introduction 00:00:24 - Circadian clock 00:08:45 - Light entrainment 00:18:19 - Cortisol 00:21:43 - Phillip's Hue 00:23:43 - Jet lag 00:29:34 - Food entrainment 00:34:02 - Time-restricted eating 00:41:49 - Muscle mass 00:44:21 - Endurance 00:46:57 - Intermittent fasting vs TRE 00:53:21 - Melatonin inhibits insulin 00:59:16 - Time-restricted eating 01:13:57 - Heart health 01:20:49 - Gut health 01:27:37 - Wrap-up SCIENCE OF HEALTHSPAN EMAIL NEWSLETTER: Receive emailed episode notifications and regular updates on the emerging science of healthspan. https://www.foundmyfitness.com/newsletter?utm_source=youtube&utm_medium=youtube&utm_campaign=panda_interview SUPPORT THE CHANNEL: Many of the magnificent resources associated with the FoundMyFitness channel exist directly as a result of our premium membership. As a premium member, listeners get access to our exclusive podcast The Aliquot, monthly Q&As, a special summary of scientific research every other week called the Science Digest, and more. Sign up to become a premium member and nurture the existence of all of the otherwise free resources provided by FoundMyFitness at https://www.foundmyfitness.com/crowdsponsor?utm_source=youtube&utm_medium=youtube&utm_campaign=panda_interview Thank you for watching! SOCIALS: https://twitter.com/foundmyfitness https://facebook.com/foundmyfitness https://instagram.com/foundmyfitness PODCAST: Apple Podcasts: https://podcasts.apple.com/us/podcast/foundmyfitness/id818198322 Spotify: https://open.spotify.com/show/5QjpaU0o1Q2MkVZwwG3y7d