Sign up to receive Peter's email newsletter: https://bit.ly/4c602k2 Become a member to receive exclusive content: https://peterattiamd.com/subscribe/ Sign up to receive Peter's email newsletter: https://peterattiamd.com/newsletter/ Peter welcomes guests David Sabatini & Matt Kaeberlein, two world-leading experts on rapamycin & mTOR. David & Matt begin by telling the fascinating story of the discovery of rapamycin & its brief history as a pharmacological agent in humans. They then unravel the function of mTOR, a central regulator of numerous biological processes, & they discuss the pathways through which rapamycin exerts its potential benefits on lifespan. They touch upon initial studies that suggested rapamycin may have geroprotective effects & the ongoing research that continues to shed light on this unique molecule. Furthermore, they discuss the elusive details surrounding the frequency & dosing of rapamycin use in humans, & Peter emphasizes his reservations about indiscriminately prescribing rapamycin as a longevity drug for patients. We discuss: -------- About: The Peter Attia Drive is a deep-dive podcast focusing on maximizing longevity, & all that goes into that from physical to cognitive to emotional health. With over 70 million episodes downloaded, it features topics including exercise, nutritional biochemistry, cardiovascular disease, Alzheimer’s disease, cancer, mental health, & more. Peter Attia is the founder of Early Medical, a medical practice that applies the principles of Medicine 3.0 to patients with the goal of lengthening their lifespan & simultaneously improving their healthspan. Learn more: https://peterattiamd.com Connect with Peter on: Facebook: http://bit.ly/PeterAttiaMDFB Twitter: http://bit.ly/PeterAttiaMDTW Instagram: http://bit.ly/PeterAttiaMDIG Subscribe to The Drive: Apple Podcast: http://bit.ly/TheDriveApplePodcasts Overcast: http://bit.ly/TheDriveOvercast Spotify: http://bit.ly/TheDriveSpotify Google Podcasts: http://bit.ly/TheDriveGoogle Disclaimer: This podcast is for general informational purposes only & does not constitute the practice of medicine, nursing, or other professional healthcare services, including the giving of medical advice. No doctor-patient relationship is formed. The use of this information & the materials linked to this podcast is at the user's own risk. The content on this podcast is not intended to be a substitute for professional medical advice, diagnosis, or treatment. Users should not disregard or delay in obtaining medical advice for any medical condition they have, & they should seek the assistance of their healthcare professionals for any such conditions. I take conflicts of interest very seriously. For all of my disclosures & the companies I invest in or advise, please visit my website where I keep an up-to-date & active list of such companies. For a full list of our registered & unregistered trademarks, trade names, & service marks, please review our Terms of Use: https://peterattiamd.com/terms-of-use/