The 2014 study by Manick and Klickstein served as a crucial turning point in favoring rapamycin as a potential longevity agent.

“it was the manic clickstein paper of december 2014 that was the real turning point in my thinking and that's really where we're going in this discussion”

Rapamycin and its derivatives may improve healthspan and reverse age-related functional declines in humans without the high risk of immunosuppression when used at appropriate doses.

“Go read the data you know go look at the data right that's just not true at the doses that that you know have been tested so far it's just that's just blatantly false right there's no evidence actually for significant side effects from rapamycin monotherapy”

Rapamycin is a proven, highly effective molecule for extending lifespan in mice, even when started in late middle age.

“giving rapamycin to a 20 month old mouse extends longevity dramatically just as dramatically as if you had started the rapamycin at a much younger age”

Rapamycin is currently considered the gold standard small molecule for impacting the aging process.

“I still think rapamy is the gold standard for a small molecule impacting aging.”

Partial inhibition of mTOR with rapamycin analogs can enhance immune function in older adults.

“what we found is if you gave it one of these mtor inhibitors for six weeks and then gave people a two week break and gave them a flu vaccination they responded better to the flu vaccination”

Rapamycin and its derivatives can improve immune function in the elderly when administered at the correct low dose.

“our approach is to address serious aging associated diseases and if we're successful the side effect will be longevity”