Do you think one bad night of sleep can really harm your body? Would you try a routine that could help you reverse aging? Today, Jay sits down with Bryan Johnson, entrepreneur and founder of Blueprint, who is redefining human health and longevity. Dubbed "the world's most measured human," Bryan shares his extraordinary journey of reversing aging and improving biological performance through science-backed methods and a meticulously designed lifestyle. Join over 750,000 people to receive my most transformative wisdom directly in your inbox every single week with my free Monk Mode newsletter. Subscribe here: https://news.jayshetty.me/subscribe In this interview, we discuss: 00:00 Intro 02:31 How Long Can a Person Live? 04:19 The Most Measured Person 06:34 Getting Sustained Hearing Impairment 09:57 Extending Life Before Conception 11:18 How Long Do We Have to Live? 14:22 Every Body Is Highly Responsive to Change 16:50 Embryo Selection Through Genetic Markers 18:12 A Generation of Microplastic 20:42 Simple Ways to Minimize the Influx of Microplastic 23:05 Don’t Drink from Water Bottles 26:01 The Significant Health Threat of Air Pollution 30:11 How Capitalism Affects Health 32:28 5 Ways to Get Better Sleep 40:12 Don’t Miss Your Deep Sleep Window 43:37 The Ill Effects of Poor Sleep 45:48 Invest in Your Health 48:12 What’s Your Protein Intake? 51:22 Bryan’s Perfect Diet 56:11 Eating 3 Meals a Day in 5 Hours 58:21 Rewire Your Taste Buds 59:19 Sensitivity to Air Quality 01:02:36 Are You Scared of Dying? 01:05:58 Prolonging Longevity 01:08:07 Ways to Manage Stress 01:11:00 You Are not Your Thoughts 01:15:37 Health Can Lead to Happiness 01:19:37 Is Reverse Aging Possible? 01:22:25 Bryan on Final Five Check out the On Purpose Merch! https://jayshettyshop.com. 100% of Proceeds are donated to National Alliance on Mental Illness. NAMI is the nation’s largest grassroots mental health organization dedicated to building better lives for the millions of Americans affected by mental illness. Episode Resources: https://www.bryanjohnson.com/ https://x.com/bryan_johnson https://www.instagram.com/bryanjohnson_/ https://www.tiktok.com/@_bryan_johnson_ https://www.youtube.com/BryanJohnson https://www.linkedin.com/in/bryanrjohnson https://protocol.bryanjohnson.com/ https://www.instagram.com/jayshetty https://www.facebook.com/jayshetty/ https://x.com/jayshetty https://www.linkedin.com/in/shettyjay/ https://www.youtube.com/@JayShettyPodcast http://jayshetty.me