GLP-1 medications are helping millions lose weight. But what happens to your metabolism, muscles, and bones long term? In this solo episode, Dr. Mindy Pelz breaks down the science behind GLP-1 drugs like Ozempic, Wegovy, and Mounjaro. She explains how these medications work, why fasting activates many of the same metabolic pathways naturally, and what women over 40 need to know before relying on rapid weight loss solutions. You’ll learn: • The hidden metabolic costs of GLP-1 medications • Why muscle preservation matters for longevity • The connection between menopause and bone density loss • How fasting naturally stimulates glucagon and ketones • The role of protein, collagen, Vitamin D, and resistance training • Natural strategies to increase your body’s own GLP-1 production This conversation is about informed choices, metabolic flexibility, and building a lifestyle that supports long-term health. ► Full show notes & resources: https://drmindypelz.com/ep341 ► Join Reset Academy: https://bit.ly/3Iu9yzB ► Books: https://drmindypelz.com/books ► Fast Like a Girl Certified Coaches: https://drmindypelz.com/find-a-coach/ REFERENCES: New England Journal of Medicine, 2019 Meta-Analysis on Fasting Journal of Clinical Endocrinology and Metabolism JAMA Study on Time-Restricted Eating Nature Reviews Disease on Bone Density and Menopause STAY CONNECTED WITH ME: Facebook:   / drmindypelz   Facebook Group:   / resetters   Substack: / drmindypelz Instagram:   / dr.mindypelz   Tiktok:   / drmindypelz   THE RESETTER PODCAST: Apple Podcast: Listen on Apple Podcasts Spotify: Listen on Spotify CREDITS: Photos: Wendy Yalom Photography Editor: Antrom Kury AFFILIATE DISCLAIMER https://drmindypelz.com/affiliate-dis... ***** Please note the following medical disclaimer: By viewing this video you understand that this video is for educational purposes only. It is not intended to substitute for professional medical advice and should not be relied on as health or personal advice. Always seek the guidance of your doctor with any questions you may have regarding your health or medical condition. You also understand and agree that the terms of our Privacy Policy and Terms of Service apply to your interaction with us.