The intestinal barrier serves as a gatekeeper to the human body. The loss of the health and integrity of this barrier influences multiple aspects of human health – including cardiometabolic function, neurological health, behavior, and more – in surprising and possibly unexpected ways. One of these ways involves lipopolysaccharide, or LPS, a bacterial product that arises in the intestine, and its interaction with far distal tissues and organs via the induction of immune mediators. Dr. Rhonda Patrick was the keynote speaker for the Metabolic Health Summit, held May 5 – 8, 2022, in Santa Barbara, California. Her presentation described the role that intestinal permeability and bacterial products play in aging, inflammation, and chronic disease. Get the show notes at https://www.foundmyfitness.com/episodes/intestinal-permeability 00:00:00 - Introduction by Dr. Dominic D'Agostino 00:03:12 - Intestinal permeability 00:05:20 - Atherosclerosis 00:10:57 - Brain 00:13:16 - Circulating LPS and behavior 00:16:13 - Toll-like receptors and inflammation 00:21:09 - Factors that affect intestinal permeability 00:27:19 - Alcohol 00:29:16 - Gluten 00:32:31 - Butyrate and dietary fiber 00:34:58 - Dietary fat 00:39:31 - Biomarkers for intestinal permeability 00:40:21 - Omega-3 fatty acids 00:47:12 - Questions & Answers LEARN MORE: Coinciding with this release, you can now find a variety of deep resources on the FoundMyFitness website for all of the topics covered in this episode. Learn about the blood-brain barrier: https://www.foundmyfitness.com/topics/blood-brain-barrier Learn about intestinal permeability: https://www.foundmyfitness.com/topics/intestinal-permeability Learn about toll-like receptors: https://www.foundmyfitness.com/topics/toll-like-receptors Learn about cerebral small vessel disease: https://www.foundmyfitness.com/topics/small-vessel-disease SUPPORT THE CHANNEL: Many of these magnificent resources exist directly as a result of our premium members. As a premium member, listeners get access to our exclusive podcast The Aliquot, monthly Q&As, a special summary of scientific research every other week called the Science Digest, and more. Sign up to become a premium member and nurture the existence of this great resource at https://www.foundmyfitness.com/premium. ABOUT THE METABOLIC HEALTH SUMMIT: Over several immersive days, MHS brings together the world’s top experts to present the latest science on a variety of topics related to metabolic health including nutrition, fasting, longevity, cancer, mental health, diabetes, optimizing human performance, the gut microbiome, and more. Learn more about their CME and CPE credited event at https://www.metabolichealthsummit.com. #obesity #endotoxemia #leakygut