Dr. Chris Thompson, MD, Professor of Medicine at Harvard Medical School, Chief of Interventional Gastroenterology at Mass General Brigham in Boston, and Co-Director of the Center for Weight Management and Wellness, is a world-renowned expert on gastroenterology, metabolism, nutrition, and obesity medicine. He explains how your GI tract regulates hunger, fullness, and blood sugar, as well as the gut microbiome, metabolic health, and weight loss. We also discuss common GI tract issues and which particular tests or interventions are actually useful. We discuss both GLP-1 medications and non-GLP-1 approaches to weight loss. Given that gut health is vital to all the organs of the body, overall health, and longevity, our discussion ought to be of interest and practical value to everyone, including, of course, those struggling with gut health or weight loss challenges. Show notes: https://go.hubermanlab.com/moMYULJ Thank you to our sponsors AG1: https://drinkag1.com/huberman Function: https://functionhealth.com/huberman Lingo: https://hellolingo.com/huberman LMNT: https://drinklmnt.com/huberman Our Place: https://fromourplace.com/huberman Timestamps 00:00:00 Dr. Chris Thompson 00:02:16 Digestive Tract, Gut Hormones & Nutrient Absorption 00:08:06 Colon Microbiome & Colon Cancer Screening 00:11:13 Sponsors: LMNT & Lingo 00:13:40 Swallowing Problems & Zenker’s Diverticula 00:16:08 Bowel Movements & Constipation 00:18:28 Fiber, Resistant Starch & the Gut Barrier 00:21:50 Intermittent Fasting & the Gut Microbiome 00:23:38 Fermented Foods, Microbial Diversity & Butyrate 00:27:12 H. pylori, Stress & Stomach Ulcers 00:30:20 GLP-1 Medications: Benefits & Limitations 00:33:42 Lower GLP-1 Doses, Weight Regain & Muscle Loss 00:37:35 GLP-1 Side Effects, Food Noise & Apathy 00:39:49 Bariatric Surgery & Medical Innovation 00:46:07 Sponsor: AG1 00:47:44 Hunger & Satiety: Ghrelin, CCK, GIP & GLP-1 00:50:01 Retatrutide & Combining Hormonal Targets 00:52:55 Ultra-Processed Foods, Overeating & Leptin 00:55:32 Incretin Discovery, Exendin-4 & the Gila Monster 00:59:35 Endoscopic Ultrasound & Pancreatic Biopsy 01:07:40 Early Metabolic Markers, CGMs & Fasting Insulin 01:13:06 Insulin Resistance & Metabolic Flexibility 01:15:53 Sponsor: Function 01:17:35 Patient Data, Screening & Treatment Adoption 01:26:31 AI, Robotics & Improving Procedures 01:29:27 Choosing a Surgeon & Measuring Procedure Quality 01:35:29 Image Guidance & Hyperspectral Imaging 01:37:19 Sponsor: Our Place 01:38:56 Diagnostics & Targeted Metabolic Treatments 01:42:45 Gastric Bypass, Foregut Exclusion & Diabetes 01:47:59 Duodenal Liners & Mucosal Resurfacing Research 01:52:58 Gut Permeability, Inflammation & Fatty Liver 01:59:39 Artificial Sweeteners, Fructose, Fats & Omega-3s 02:05:00 Resistance Training, Zone 2 Cardio & Intervals 02:06:31 Weight Set Point & Metabolic Adaptation 02:08:13 Endoscopic Sleeve Gastroplasty & Fundus Ablation 02:10:30 Magnetic Intestinal Connections & Combined Treatments 02:16:52 GLP-1 Gene Therapy Research 02:22:13 Innovation, Problem Solving & Teamwork 02:25:58 Zero-Cost Support, Sponsors & Neural Network Newsletter #hubermanlab #science #guthealth Disclaimer & Disclosures: https://www.hubermanlab.com/disclaimer