Regular ingestion of caffeine increases the number of D2 and D3 dopamine receptors, which makes circulating dopamine more effective.

“Turns out that regular ingestion of caffeine at safe and appropriate levels, about a hundred to 250 milligrams is going to increase the number of D2 and D3 dopamine receptors.”

Supplements should be taken in single-ingredient formulations to allow for precise dosing and to understand the effects of specific compounds.

“If you're going to develop a supplementation protocol you're going to want to focus mainly on using single ingredient formulations with single ingredient formulations you can devise the most logical and effective and costeffective supplementation regimen for your goals”

Supplements are merely training wheels that help the body learn processes and are not strictly necessary once an individual reaches a certain level of health and nervous system regulation.

“Ask not what your supplement can do for you, but what you can do for your supplement. I'm the supplement guy, and I'm going to tell you that you don't need supplements. The supplements are the training wheels.”

Tim Ferriss advises treating ketone monoester supplementation with caution because of mounting evidence suggesting it can be unhealthy for the liver in high doses.

“There's mounting evidence that it's pretty unhealthy for your liver. So just use in moderation in terms of ketone supplementation.”