The efficacy of a psilocybin experience depends significantly on the 'set and setting,' including the presence of support and the use of music.

“the structure of the journey who's present, who's not present, eyes open or eyes closed, the particular music that's played. All of those features make up part of a larger neuroplasticity trigger of which psilocybin is critical.”

Psychedelics offer a therapeutic benefit by temporarily disabling the default mode network, allowing individuals to step outside their reality model and re-engineer it in a more functional way.

“the core of the therapeutic use of the therapeutic promise if you will of psychedelics is they let you step out of this reference frame temporarily look at it as though you know as though you're separated it and it helps give you insights as to you know your your existential situation so it enables ”