Neuroinflammation is a fundamental driver of Alzheimer's disease that may be an essential therapeutic target for both prevention and treatment.

“I really think there's something to be said. I think neuroinflammation is going to be the new frontier in terms of how we're going to deal with um and even prevent entirely Alzheimer's disease.”

Exercise prevents neuroinflammation by altering the metabolism of tryptophan to avoid producing quinolinic acid.

“muscle when you exercise muscle um creates uh turns curine into a metabolic byproduct that cannot be converted into quintic acid so literally and by by the way this quintic acid which goes into the brain and creates neuroinflammation is um also associated with depression”

Nicotine may provide neuroprotective benefits by inhibiting certain inflammosomes that contribute to post-operative cognitive dysfunction.

“So there's some evidence that nicotine can have some neuro anti-inflammatory okay >> benefits and activates some inflammosome or like inhibit some inflammosomes that are important to neuroinflammation.”