Social connection circuitry is deeply linked to the brain's need for safety and acceptance, and it involves interconnected brain regions that evolved for bonding and predicting outcomes.

“The circuits that are responsible for feelings of social connectedness are deeply, deeply rooted in our need for safety. We could say this about any organism, but humans, included, need two things, I believe. We need the feeling of safety and acceptance.”

Humans are chemically wired to feel social reward through oxytocin, serotonin, and dopamine, which reinforces positive social behavior.

“We have these social reward systems in our brain where when we have positive interactions, we're around others, basically these three neurotransmitters that many people have probably heard of, oxytocin, serotonin and dopamine, those three work together to create this sense of social reward.”