Sign up to receive Peter's email newsletter: https://bit.ly/4c602k2 Original release date: 10/8/2018 In this episode, Dave Feldman, discusses his journey from software engineer to n=1 experimenter, his experience with low-carbohydrate diets, and his hypothesis that cholesterol levels are influenced by energy metabolism. Note: this podcast gets technical at times and refers to many visuals during the discussion. The graphics, figures, and tables alluded to are provided in the show notes. In addition, there is commentary by Thomas Dayspring, M.D., in the show notes, providing corrections, clarifications, and amplification. Dave Feldman provided many graphics and some additional comments that are included in the show notes. We discuss: -Peter’s synthesis of Dave’s energy model [5:00]; -Dave’s lipid energy model; -Dave’s inversion pattern experiments; -Dave’s journey from software engineer to cholesterol enthusiast [15:00]; -Standard blood panels, sterol panels, and what moves the needle when it comes to particle numbers [18:30]; -Hyper-responders [20:00]; -Lipoprotein transport [33:45]; -The lean mass hyper-responder phenotype [47:30]; -The progression of atherosclerosis, CAC, and CIMT [52:30]; -Testing for oxidized LDL [55:30]; -All-cause mortality and clinical endpoints [1:01:15]; -What does “LDL as causal” mean? [1:05:15]; -Dave’s low carb cholesterol challenge and drug & genetic study qualifications [1:13:15]; -If all other markers are in a healthy range, but LDL-P is high, is the patient at risk? A couple of case studies, and a self-experiment [1:27:30]; -Peter’s three-day exercise and ketosis experiment [1:41:00]; -What are remnant lipoproteins? [1:45:00]; -What might cause lean mass hyper-responders to have higher LDL particle numbers? [1:53:30]; -A case study from Dave of a lean mass hyper-responder [1:56:30]; -Mass balance and cholesterol flux [2:05:30]; -Can a higher degree of cholesterol explain the lean mass hyper-responder phenotype? [2:10:00]; -Peter’s LDL during his keto-fast-keto experiment [2:13:30]; -Does substituting saturated fats with monounsaturated fats lower LDL-P and LDL-C? [2:15:45]; -Dave’s carb-swap experiments [2:22:15]; -Dave’s carotid intima-media thickness tests [2:41:15]; -Looking for studies that stratify for high HDL-C and low TG alongside low and high LDL-C [2:53:00]; and -More Show notes page: https://peterattiamd.com/davefeldman/ For the transcript of this episode where there is more commentary from Tom Dayspring: https://peterattiamd.com/davefeldmantranscript/ About: The Peter Attia Drive is a weekly, ultra-deep-dive podcast focusing on maximizing health, longevity, critical thinking…and a few other things. With over 10 million episodes downloaded, it features topics including fasting, ketosis, Alzheimer’s disease, cancer, mental health, and much more. Peter is the founder of Attia Medical, PC, a medical practice with offices in San Diego and New York City, focusing on the applied science of longevity. The practice applies nutritional biochemistry, exercise physiology, sleep physiology, techniques to increase distress tolerance, lipidology, pharmacology, and four-system endocrinology to increase lifespan (delaying the onset of chronic disease), while simultaneously improving healthspan (quality of life). Learn more: https://peterattiamd.com/ Subscribe to receive exclusive subscriber-only content: https://peterattiamd.com/subscribe/ Sign up to receive Peter's email newsletter: https://peterattiamd.com/newsletter/ Connect with Peter on: Facebook: http://bit.ly/PeterAttiaMDFB Twitter: http://bit.ly/PeterAttiaMDTW Instagram: http://bit.ly/PeterAttiaMDIG Subscribe to The Drive: Apple Podcast: http://bit.ly/TheDriveApplePodcasts Overcast: http://bit.ly/TheDriveOvercast Spotify: http://bit.ly/TheDriveSpotify Google Play: http://bit.ly/TheDriveGooglePlay