⏳ David A. Sinclair, PhD, is a professor in the Department of Genetics at Harvard Medical School and co-director of the Paul F. Glenn Center for the Biological Mechanisms of Aging. He is the co-founder of the journal Aging, where he serves as co-chief editor. Dr. Sinclair's work focuses on understanding the mechanisms that drive human aging and identifying ways to slow or reverse aging's effects. In particular, he has examined the role of sirtuins in disease and aging, with special emphasis on how sirtuin activity is modulated by compounds produced by the body as well as those consumed in the diet, such as resveratrol. His work has implications for human metabolism, mitochondrial and neurological health, and cancer. Dr. Sinclair obtained his doctoral degree in molecular genetics at the University of New South Wales, Sydney, in 1995. Since then, he has been the recipient of more than 25 prestigious honors and awards and in 2014 was named as one of TIME Magazine’s 100 most influential people in the world. Dr. Sinclair recently authored the book, Lifespan: Why We Age – and Why We Don't Have To. In this episode, Dr. David Sinclair discusses exciting new findings in the field of aging research, with special emphasis on the roles of sirtuins, resveratrol, and NAD+. EPISODE LINKS: Show notes and transcript: https://www.foundmyfitness.com/episodes/david-sinclair?utm_source=youtube&utm_medium=youtube&utm_campaign=sinclair_interview "Lifespan: Why We Age – and Why We Don't Have To." Book: https://www.simonandschuster.com/books/Lifespan/David-A-Sinclair/9781501191978 PODCAST INFO: Email: https://www.foundmyfitness.com/newsletter?utm_source=youtube&utm_medium=youtube&utm_campaign=sinclair_interview Apple Podcasts: https://podcasts.apple.com/us/podcast/049-dr-david-sinclair-on-informational-theory-of/id818198322?i=1000532219203 Spotify: https://open.spotify.com/episode/3QgznDpyAQf4RBaGx54et7 Full interview playlist: https://www.youtube.com/playlist?list=PLJEEAVzHu9KzgkQbe2Thh35VU-HCiId_s Clips playlist: https://www.youtube.com/playlist?list=PLrGxo-5Uw8gI9-1IStYEvNxVukKxZBlmi - Learn more in these overview articles: Sirtuins: https://www.foundmyfitness.com/topics/sirtuin?utm_source=youtube&utm_medium=youtube&utm_campaign=sinclair_interview Resveratrol: https://www.foundmyfitness.com/topics/resveratrol?utm_source=youtube&utm_medium=youtube&utm_campaign=sinclair_interview Fasting: https://www.foundmyfitness.com/topics/fasting?utm_source=youtube&utm_medium=youtube&utm_campaign=sinclair_interview NAD+: https://www.foundmyfitness.com/topics/nad?utm_source=youtube&utm_medium=youtube&utm_campaign=sinclair_interview Nicotinamide riboside: https://www.foundmyfitness.com/topics/nicotinamide-riboside?utm_source=youtube&utm_medium=youtube&utm_campaign=sinclair_interview Nicotinamide mononucleotide: https://www.foundmyfitness.com/topics/nicotinamide-mononucleotide?utm_source=youtube&utm_medium=youtube&utm_campaign=sinclair_interview Chapters: 00:00:00 - Introduction 00:00:36 - Activating longevity genes 00:05:02 - Sirtuin activation 00:07:19 - Fasting, caloric restriction, and exercise 00:10:56 - NAD+ 00:16:00 - Resveratrol 00:20:00 - Epigenetics 00:36:22 - Boosting NAD+ 00:41:11 - Excess calories accelerates 00:44:26 - Resveratrol slows aging 00:51:00 - NR & NMN in aging 01:00:05 - Sleep improves glucose metabolism SCIENCE OF HEALTHSPAN EMAIL NEWSLETTER: Receive emailed episode notifications and regular updates on the emerging science of healthspan. https://www.foundmyfitness.com/newsletter?utm_source=youtube&utm_medium=youtube&utm_campaign=sinclair_interview SUPPORT THE CHANNEL: Many of the magnificent resources associated with the FoundMyFitness channel exist directly as a result of our premium membership. As a premium member, listeners get access to our exclusive podcast The Aliquot, monthly Q&As, a special summary of scientific research every other week called the Science Digest, and more. Sign up to become a premium member and nurture the existence of all of the otherwise free resources provided by FoundMyFitness at https://www.foundmyfitness.com/crowdsponsor?utm_source=youtube&utm_medium=youtube&utm_campaign=sinclair_interview Thank you for watching! SOCIALS: https://twitter.com/foundmyfitness https://facebook.com/foundmyfitness https://instagram.com/foundmyfitness PODCAST: Apple Podcasts: https://podcasts.apple.com/us/podcast/foundmyfitness/id818198322 Spotify: https://open.spotify.com/show/5QjpaU0o1Q2MkVZwwG3y7d ⏳ #aging #longevity #fasting #epigenetics #NMN #NR 🧬