Aging can be reversed by resetting the epigenome to an earlier, youthful state.

“What I think he's doing is what we're doing in the lab, which is getting those proteins that have moved around and lost their way to go back to where they were when they were young and then reset the methylation clock. And now a cell doesn't just think it's young. It's literally young.”

Sulforaphane is a potent activator of the Nrf2 pathway that warrants investigation in longevity studies.

“Sulforaphane is, to my knowledge, the most potent dietary...naturally occurring dietary activator of Nrf2 pathway.”

Genes account for only about 20% of life expectancy, while the remaining 80% is largely determined by environment, lifestyle, and social factors.

“only about 20% of how long we live is dictated by our genes, 80% is something else”

Future clinical trials in aging should utilize quantitative, functional endpoints that reflect significant declines in quality of life to better demonstrate the efficacy of gero-protective interventio

“I would try to identify the best single endpoint or set of endpoints that correspond to a significant functional deficit that impacts quality of life in older people and assess whether or not my intervention improves that”

Rapamycin is a promising candidate for longevity, but it is not yet proven to be geroprotective in humans.

“I'm going to put Rapa in the promising category”

Altos Labs is a legitimate and important investment in groundbreaking science that could fundamentally rewrite the course of humanity.

“this is going to be the year i think this will be the front cover of a lot of magazines this year as people realize the that this is real and that it's getting commercialized”

Targeted gene therapies that manipulate biological markers like follistatin can significantly reverse biological age and extend health span.

“we showed in our phase one trial that patients over the age of 60 on average reduce their intrinsic biological age by 12 years which is actually incredible”

Research on simple organisms like worms provides critical insights into aging mechanisms that are likely conserved in humans.

“making all these connections to disease and all the model organism people coming to this conclusion, working in flies and mice and yeast even that these are basic mechanisms of aging. They're likely to be playing out in humans as well”