Blog post with audio player, show notes, and transcript: https://www.preposterousuniverse.com/podcast/2020/03/09/87-karl-friston-on-brains-predictions-and-free-energy/ Patreon: https://www.patreon.com/seanmcarroll If you tell me that one of the world’s leading neuroscientists has developed a theory of how the brain works that also has implications for the origin and nature of life more broadly, and uses concepts of entropy and information in a central way — well, you know I’m going to be all over that. So it’s my great pleasure to present this conversation with Karl Friston, who has done exactly that. One of the most highly-cited neuroscientists now living, Friston has proposed that we understand the brain in terms of a free energy principle, according to which our brains are attempting to model the world in such a way as to minimize the amount of surprise we experience. It’s a bit more complicate than that, but I think we made great headway in explicating some very profound ideas in a way that should be generally understandable. Karl Friston received his medical degree from King’s College Hospital, London. He is currently Professor at the Institute of Neurology, University College London, and Wellcome Principal Research Fellow and Scientific Director of the Wellcome Trust Centre for Neuroimaging. Among his major contributions are statistical parametric mapping, voxel-based morphometry, and dynamical causal modeling. He is a Fellow of the Royal Society, of the Academy of Medical Science, and of the Royal Society of Biology. Among his awards are the Young Investigators Award in Human Brain Mapping, the Minerva Golden Brain Award, the Weldon Memorial Prize, the Charles Branch Award, and the Glass Brain Award for human brain mapping.