Dr. Rhonda Patrick interviews Dr. Judy Campisi, a professor of biogerontology at the Buck Institute for Research on Aging, a co-editor in chief of the Aging Journal and an expert on the role of cellular senescence in the aging process and development of cancer. Cellular senescence is so important when we discuss aging and cancer because as our cells accumulate damage, which naturally happens as we age (even as a consequence of the energy generating processes and immune cell activation), there's only so many outcomes that we can expect. The first possibility is that the cells can die. The next is that they can become senescent where they stop dividing but stay alive all-the-while secreting molecules that influence surrounding tissue… or the worst of all possible outcomes, the cells can really go off the rails and become malignant. What's interesting is that, while accumulating senescent cells is inevitable, there are varying strategies of how to tackle senescence and this is of great interest to the field of aging. There are ways to clear out senescent cells with drugs or even dietary and lifestyle interventions. Not only are there ways to kill senescent cells, there are also ways to influence what sort of molecules they produce, possibly limiting the inflammatory ones… even without killing them. In this podcast, Dr. Campisi shares with us many insights on how senescence may be key to our understanding of cancer and aging. EPISODE LINKS: Show notes and transcript: https://www.foundmyfitness.com/episodes/judy-campisi?utm_source=youtube&utm_medium=youtube&utm_campaign=campisi_interview Dr. Judith Campisi's Lab @ Buck: http://www.buckinstitute.org/campisiLab PODCAST INFO: Email: https://www.foundmyfitness.com/newsletter?utm_source=youtube&utm_medium=youtube&utm_campaign=campisi_interview Apple Podcasts: https://podcasts.apple.com/us/podcast/foundmyfitness/id818198322?i=1000532219205 Spotify: https://open.spotify.com/episode/69n9HBIRRdj3XyXUufNeY2?si=U0KF4K2bRoCSlVvcdGUAjQ&nd=1 Full interview playlist: https://www.youtube.com/playlist?list=PLJEEAVzHu9KzgkQbe2Thh35VU-HCiId_s Clips playlist: https://www.youtube.com/playlist?list=PLrGxo-5Uw8gI9-1IStYEvNxVukKxZBlmi Chapters: 00:00:00 - Introduction 00:00:52 - Drivers of aging 00:02:40 - Inflammation 00:08:06 - Senescence 00:18:57 - Lifespan vs healthspan 00:25:20 - Drivers of senescence 00:30:34 - Combating senescence with fasting 00:42:17 - Exercise extends lifespan 00:48:50 - Measuring senescence 00:54:45 - NAD+ boosters 00:56:00 - Fasting mimetics 00:57:00 - Cancer in animals SCIENCE OF HEALTHSPAN EMAIL NEWSLETTER: Receive emailed episode notifications and regular updates on the emerging science of healthspan. https://www.foundmyfitness.com/newsletter?utm_source=youtube&utm_medium=youtube&utm_campaign=campisi_interview SUPPORT THE CHANNEL: Many of the magnificent resources associated with the FoundMyFitness channel exist directly as a result of our premium membership. As a premium member, listeners get access to our exclusive podcast The Aliquot, monthly Q&As, a special summary of scientific research every other week called the Science Digest, and more. Sign up to become a premium member and nurture the existence of all of the otherwise free resources provided by FoundMyFitness at https://www.foundmyfitness.com/crowdsponsor?utm_source=youtube&utm_medium=youtube&utm_campaign=campisi_interview Thank you for watching! SOCIALS: https://twitter.com/foundmyfitness https://facebook.com/foundmyfitness https://instagram.com/foundmyfitness PODCAST: Apple Podcasts: https://podcasts.apple.com/us/podcast/foundmyfitness/id818198322 Spotify: https://open.spotify.com/show/5QjpaU0o1Q2MkVZwwG3y7d