Insulin is the primary hormone regulating energy storage and it causes insulin resistance when constantly spiked by poor diet.

“Insulin as a hormone is the one metabolic hormone to rule them all. Insulin will tell every single cell of the body what it needs to do with energy. And insulin is so determined to store energy that it is directing calories to be stored in tissues like fat or in the liver”

Excess insulin is a chronic disease maker that drives conditions like high blood pressure, cancer, and brain deterioration.

“But when you have excess insulin, it's a chronic disease maker. It is what makes high blood pressure. It is what makes cancer. It is what makes debris in the brain, which is linked to depression, brain fog, Alzheimer's, and Parkinson's.”

Insulin resistance is a common root cause for most chronic diseases.

“I unapologetically embrace the view that to some degree insulin resistance is a common root cause for most chronic diseases.”

Hyperinsulinemia is a critical underlying issue in metabolic dysfunction, and patients often show signs of metabolic compromise long before glucose levels become abnormal.

“I have in the past three years really started to pay much closer attention to Sisseton see creatinine along with micro albumin for exactly this reason because it sort of occurred to me in a momentary insight that if my interest is in longevity”

Insulin resistance is a foundational issue in type 2 diabetes that requires tissue-specific definition because insulin regulates many distinct metabolic processes.

“one of the challenges with the term insulin resistance is as you said it's a vague term and it's non-specific there two problems in diabetes one is you don't make enough insulin the other is your insulin resistant”

Hyperinsulinemia is the underlying problem, and insulin resistance is better understood as an overflow of glucose within cells rather than a lack of cellular sensitivity.

“it's not a sort of underfill problem it's an overflow problem because there's two possible way so we say there insulin resistant because the glucose does not go into the cell”

Fructose-induced energy depletion and leptin resistance are key drivers of insulin resistance and obesity.

“fructose lowers the energy and keeps the energy levels low and this is due to this runaway renegade enzyme fructokinase that just takes all the atp it can”

Time-restricted eating can lead to improvements in hemoglobin A1C, a key marker of glucose regulation and metabolic health.

“We've actually seen probably our most consistent effect on something called Hemoglobin A1C, which is a marker of your average glucose, over about three months.”