New orexin-receptor antagonist drugs, or DORA class medications, represent a beneficial advance in sleep treatment because they promote naturalistic sleep and support brain detoxification.

“what they realized is that what we can do if this chemical orexin, this wakefulness volume button in the brain, is a problem in insomnia patients, what if we were to just develop a drug that doesn't sedate the cortex like Ambien? Instead, it goes down into the brainstem where the center for orexin i”