Metabolic changes in cancer are likely a consequence of oncogenic drivers rather than the primary cause of cancer.

“I think that the event that is driving this I think that the the I think the oncogenic effect is the is the driver and I think the metabolism allows the cancer to be even more adaptable to the scenarios that you describe”

Cancer is primarily a metabolic disease caused by mitochondrial respiratory dysfunction rather than primarily a genetic disease.

“is cancer primarily a metabolic disease meaning a disease whose origin arrives in the mitochondria or in the metabolic machinery of the cell or is it primarily a genetic disease where sometimes you will and sometimes you won't sustain mitochondrial damage”

Metabolic therapies combined with immunotherapy or traditional treatments show promise for treating cancer by exploiting the metabolic vulnerabilities of tumors.

“I'm a big believer that you know there's metabolic limitations on immune response to cancer and that if we can overcome them we will have major therapeutic benefits”

Hyperinsulinemia is a fundamental piece of the cancer puzzle that ties together obesity and cancer cell proliferation.

“in my book insulin is sort of the explanation which ties it all together which obviously not all cancers are caused by insulin and you know insulin's role according to some scientists is only indirect it causes the obesity and the obesity causes other hormonal changes in inflammation but but one way”