Sleep deprivation causes emotional volatility by weakening the connection between the medial prefrontal cortex and the amygdala, reducing rational control.

“without sleep we found that that connection had been severed and so it was almost as though without sleep you become all emotional gas pedal and too little regulatory control break”

Creatine supplementation helps mitigate the negative cognitive effects of sleep deprivation by maintaining brain bioenergetics.

“a classic study was done last year when they gave 30 g to a group of young individuals who volunteered to be sleep deprived for 21 hours. And that level of creatine increased creatine levels in the brain and it offset some of the negative effects.”

Johann contends that the significant decline in sleep quality and duration is a major contributor to the current attention crisis.

“so we know that sleep's got worse we know that sleep is crucial for attention um does that mean it is true to say that we have got an attention crisis and he said even if nothing else to change in society and this is only one of the twelve changes even if nothing else to change in society that alone”

All nighters are only productive when there is a sense of urgency.

“I think there's like this this response for the the human brain where it's like if you have a need you know all other all other needs do go away you can't pretend yourself into that mode but once you're in that mode it's like [ __ ] I got to get done whether it's like adrenaline or just like this ki”

He considers the physical pain in his knees after cleaning and exercise to be potentially linked to his age.

“I think I'm I hate to say this, Wade, as a guy who just became another year older on that unfortunate day where you instantly boom age. We are getting older and I have a feeling that that might just be an age thing as opposed to what you were doing specifically.”