The protein encoded by the APOE4 isoform is dysfunctional and contributes to both cardiovascular and neurodegenerative disease risk.

“what we talk about in this episode is what that actual protein does and why is it that someone with the APO E4 Gene codes for a version of that protein which by the way only differs in one amino acid from the one coded for by apoe3 and we talk about why the protein that is coded by the apoe for isof”