Science says eating just one meal per day can improve your health. Learn more at https://highintensityhealth.com/OMAD ----- Ben Bikman, PhD is back to take a deep dive into new aspects of glucose metabolism, ketosis and fatty oxidation. We also explore nuances around protein and mTOR in the context of cancer. ➢This episode is brought to you by Butcher Box: suppliers of 100% grass-fed and feed-lot-free beef, chicken and pork: http://butcherbox.com/hih-2 **they have a great deal for new customers, including $75 in top-tier cuts of meat when you register for a new account. Connect with Ben: ➢https://twitter.com/benbikmanphd ➢ http://bikmanlab.byu.edu/Home.aspx Interested in MCT oil and exogenous ketones? ➢ https://perfectketo.com/hih Use Promo code: HIH20 to save 20% on your order ➢ Best Omega-3 Fish Oil: https://amzn.to/2xs08CC My Fav Blue Blocking Sun-Glasses: https://amzn.to/2Tn3hdC ---------------------------------- TOOLS & VIDEO GEAR----------------------------------------- Best Vlog & FB Live Stabilizer: https://amzn.to/2wcoJXZ Nice HD Camera Canon 6D Mark II https://amzn.to/2JyxrG5 Interview Cam C100 ii: https://amzn.to/2EC5NE8 Best Lens Ever: https://amzn.to/2IJ9WZC Vlog lens: Canon EF-S 17-55mm f/2.8 IS: https://amzn.to/2IGlfSo Dope Lens - Canon 85mm f/1.4L IS: https://amzn.to/2IFRG3h Good Audio: Rode VMPRPLUS Videomic Pro: https://amzn.to/2v9W9cm -----------------------------------------Lets Connect-------------------------------------- ➢ iTunes Podcast: https://highintensityhealth.com/itunes ➢ Instagram https://www.instagram.com/metabolic_mike ➢ Facebook https://www.facebook.com/MikeMutzelMS -------------------------------------- Key Timestamps---------------------------------- 05:49 We are applying the low carb ketogenic diet in bizarre ways by dumping oil into their drinks. There is no other nutritional value to the oils. 07:45 Fasted exercise stimulates glucagon. 09:37 People may be confusing gluconeogenesis with an insulinogenic effect. 10:40 If you have ketogenesis happening, you have gluconeogenesis. 14:10 True clinical hypoglycemia is remarkably uncommon. 18:22 If you have food in your gut during exercise, your body is conflicted about sending blood to your muscles or your guts. 19:57 Protein increases insulin and glucagon. 21:02 Glucagon is catabolic of fat tissue. 23:00 Glucagon activates lipolysis, increasing free fatty acids. Hormones tell the body what to do with energy. 23:54 Acetyl-CoA is the branch point of all metabolic processes. Catecholamines and glucagon counter insulin, but insulin reigns supreme. 25:40 Consuming meat or saturated fat does not create lipotoxicity or insulin resistance. 30:17 It is easier to induce insulin mediated lipotoxicity with a vegan diet than a ketogenic diet due to the high carb content. 30:43 Excess palmitate can create an excess of ceramides, as can hyperinsulinemia directly. 32:39 Triglycerides do not effect insulin sensitivity. 33:45 There are more ceramides in sedentary, obese, insulinemic individuals. 34:53 Alpha cells become insulin resistant because of a ceramide accumulation. 35:52 In type 1 diabetes, where you are not making insulin in the microenvironment, too much glucagon is produced, elevating glucose. 37:30 Both insulin and glucagon are high in type 2 diabetics. It should be one or the other. 40:15 Exogenous ketones shut down your body’s ability for hepatic ketogenesis. Pulsed exogenous ketones can be helpful with TBI or other neurological issues. 41:55 Glucagon activates processes that are involved in mitochondrial biogenesis. 44:47 As you become more fat adapted, your body becomes more efficient and ketone baseline levels drop. 44:57 Once ketones are detectible from a low carb diet, metabolic pathways have been activated and insulin is low. 47:53 You cannot store ketones if insulin is low. 51:54 Any cell that you want to maintain and grow requires mTOR. Insulin promotes mTOR activation. 52:55 Leucine is a good mTOR activator in muscle. 53:22 A cancer cell will grow with chronic mTOR activation, but it is not the cause of the cancer. 54:41 Protein consumption does not correlate to cancer incidence. 55:41 Animal products are higher in protein and we absorb more. Plants are relatively deficient in protein and we do not absorb it effectively. 59:17 Carnitine is involved in lipid transport. 01:00:41 Leucine is the most anabolic amino acid and is a ketogenic amino acid. 01:01:22 Red meat is a great source of carnitine. Carnitine accelerates ketogenesis. 01:03:55 Cold induced uncoupling can stimulate mitochondrial uncoupling in muscle. 01:05:19 Ketones induce mitochondrial uncoupling in fat tissue, telling it that it is okay to waste energy. 01:08:56 Cold exposure has an immune benefit and a cognitive benefit, as well as the metabolic benefit. 01:15:39 A main cause of endotoxemia can be LPS (lipopolysaccharide). This is accelerated when your body is absorbing lipid.