My guest is Dr. Kyle Gillett, MD, a dual board-certified physician in family medicine and obesity medicine and an expert in optimizing hormone levels to improve overall health and well-being in both men and women. We discuss how to improve hormones using behavioral, nutritional and exercise-based tools and how to safely and rationally approach supplementation and hormone therapies. We also explore testosterone and estrogen and how those hormones relate to fertility, mood, aging, relationships, disease pathologies, thyroid hormone, growth hormone, prolactin, dopamine and peptides that impact physical and mental health and vitality across the lifespan. The episode is rich with scientific mechanisms and practical tools for people to consider. For an up-to-date list of our current sponsors, please visit our website: https://www.hubermanlab.com/sponsors. Previous sponsors mentioned in this podcast episode may no longer be affiliated with us. Social & Website Instagram: https://www.instagram.com/hubermanlab Threads: https://www.threads.net/@hubermanlab Twitter: https://twitter.com/hubermanlab Facebook: https://www.facebook.com/hubermanlab TikTok: https://www.tiktok.com/@hubermanlab Website: https://www.hubermanlab.com Newsletter: https://www.hubermanlab.com/newsletter Apple Podcasts: https://apple.co/3thCToZ Spotify: https://spoti.fi/3PYzuFs Dr. Kyle Gillett Instagram: https://www.instagram.com/kylegillettmd YouTube: https://bit.ly/3v65nSQ TikTok: https://www.tiktok.com/@gilletthealth LinkedIn: https://www.linkedin.com/in/kylegillettmd Clinic: https://gilletthealth.com Timestamps 00:00:00 Dr. Kyle Gillett, MD, Hormone Optimization 00:03:10 The Brain-Body Contract 00:04:10 Thesis, InsideTracker, ROKA 00:08:24 Preventative Medicine & Hormone Health 00:14:17 The Six Pillars of Hormone Health Optimization 00:17:14 Diet for Hormone Health, Blood Testing 00:20:21 Exercise for Hormone Health 00:21:06 Caloric Restriction, Obesity & Testosterone 00:23:55 Intermittent Fasting, Growth Hormone (GH), IGF-1 00:29:08 Sleep Quality & Hormones 00:35:03 Testosterone in Women 00:38:55 Dihydrotestosterone (DHT), Hair Loss 00:43:46 DHT in Men and Women, Turmeric/Curcumin, Creatine 00:50:10 5-Alpha Reductase, Finasteride, Saw Palmetto 00:52:30 Hair loss, DHT, Creatine Monohydrate 00:55:07 Hair Regrowth, Male Pattern Baldness 00:58:12 Polycystic Ovary Syndrome (PCOS), Inositol, DIM 01:04:00 Oral Contraception, Perceived Attractiveness, Fertility 01:10:31 Testosterone & Marijuana or Alcohol 01:14:27 Sleep Supplement Frequency 01:15:34 Testosterone Supplementation & Prostate Cancer 01:20:24 Prostate Health, Dietary Fiber, Saw Palmetto, C-Reactive Protein 01:24:05 Prostate Health & Pelvic Floor, Viagra, Tadalafil 01:30:54 Testosterone Replacement Therapy (TRT) 01:35:17 Estrogen & Aromatase Inhibitors, Calcium D-Glucarate, DIM 01:39:28 Lifestyle Factors to Increase Testosterone/Estrogen Levels, Dietary Fats 01:45:34 Aromatase Supplements: Ecdysterone, Turkesterone 01:47:04 Tongkat Ali (Long Jack), Estrogen/Testosterone levels 01:52:25 Fadogia Agrestis, Luteinizing Hormone (LH), Frequency 01:56:44 Boron, Sex Hormone Binding Globulin (SHBG) 01:58:13 Human Chorionic Gonadotropin (hCG), Fertility 02:04:18 Prolactin & Dopamine, Pituitary Damage 02:08:34 Augmenting Dopamine Levels: Casein, Gluten, Vitamin E, Vitamin B6 (P5P) 02:12:30 L-Carnitine & Fertility, TMAO & Allicin (Garlic) 02:18:19 Blood Test Frequency 02:19:41 Long-Term Relationships & Effects on Hormones 02:25:33 Nesting Instincts: Prolactin, Childbirth & Relationships 02:29:05 Cold & Hot Exposure, Hormones & Fertility 02:32:34 Peptide Hormones: Insulin, Tesamorelin, Ghrelin 02:37:24 Growth Hormone-Releasing Peptides (GHRPs) 02:39:38 BPC-157 & Injury, Dosing Frequency 02:45:23 Uses for Melanotan 02:48:21 Spiritual Health Impact on Mental & Physical Health 02:54:18 Caffeine & Hormones 02:56:19 Neural Network Newsletter, Zero-Cost Support, YouTube Feedback, Spotify Review, Apple Reviews, Sponsors, Patreon, Thorne, Instagram, Twitter, Brain-Body Contract #HubermanLab #Health #Hormones Disclaimer: https://www.hubermanlab.com/disclaimer Title Card Photo Credit: Mike Blabac - https://www.blabacphoto.com Audio Engineering: Joel Hatstat at High Jump Media