In this episode, I explain how to design a supplementation protocol to support maximum mental and physical health and performance depending on your specific needs, nutrition, lifestyle and finances. When most people hear about “supplements,” they think they are vitamin supplements, but there are many compounds that are powerful and sold over-the-counter that can enhance our health in performance and that can’t be obtained from foods. First, I discuss “foundational” supplements to support overall health, including water and fat-soluble vitamins, minerals, digestive enzymes, adaptogens, and prebiotics/probiotics. Then I explain how to use single-ingredient supplements to enhance specific aspects of your physiology, such as aiding sleep, cognitive enhancement, and focus supporting healthy hormone levels (e.g., testosterone, estrogen and growth hormone, thyroid). Finally, I explain when it makes sense to add supplements to your lifestyle and discuss how best to use supplements, including how to determine dosage, sourcing, continuous schedules and cycling, and how to layer different supplements most effectively. This episode will explain how to design the safest, most biologically effective, cost-effective supplementation protocol to meet your particular goals and support your overall health, including vitality and longevity. #HubermanLab #Supplements #Science Thank you to our sponsors AG1 (Athletic Greens): https://athleticgreens.com/huberman LMNT: https://drinklmnt.com/huberman Helix Sleep: https://helixsleep.com/huberman InsideTracker: https://www.insidetracker.com/huberman Supplements from Momentous https://www.livemomentous.com/huberman Huberman Lab Premium https://hubermanlab.com/premium Social & Website Instagram - https://www.instagram.com/hubermanlab Twitter - https://twitter.com/hubermanlab Facebook - https://www.facebook.com/hubermanlab TikTok - https://www.tiktok.com/@hubermanlab Website - https://hubermanlab.com Newsletter - https://hubermanlab.com/neural-network Articles Eurycoma longifolia (Jack) Improves Serum Total Testosterone in Men: A Systematic Review and Meta-Analysis of Clinical Trials: https://bit.ly/3QnuCdJ Resources Examine: https://examine.com Timestamps 00:00:00 Supplements 00:03:38 Hierarchy of Tools/Interventions, Developing a Supplementation Protocol 00:11:51 Momentous, LMNT, Helix Sleep 00:15:38 Role of Supplements, Foundational Supplements, Water/Fat-Soluble Vitamins 00:21:07 Supplement Considerations: Cost, Nutrition & Schedule 00:25:25 Foundational Supplements, Digestive Enzymes, Adaptogens 00:28:04 Gut Microbiome, Probiotics/Prebiotics & Nutrition 00:33:06 Supplements for Gut Microbiome, Brain Fog 00:35:59 InsideTracker 00:36:44 Adaptogens & Broad-Spectrum Foundational Supplements 00:38:35 Core Supplement Questions & Meeting Foundational Needs 00:43:45 Supplements to Support Sleep: Myo-Inositol, Theanine 00:50:52 Supplements for Falling Asleep: Magnesium Threonate/Bisglycinate, Apigenin 00:55:55 Melatonin Caution 00:58:11 Supplement Dependency?, Placebo Effects 01:02:45 AG1 (Athletic Greens) 01:03:53 Nutrition & Behavior for Hormone Health 01:08:59 Hormone Health: Shilajit, Ashwagandha, L-Carnitine, Maca Root 01:12:48 Growth Hormone: Behaviors, Arginine, Prescriptions 01:16:04 Testosterone/Estrogen: Fadogia Agrestis; Bloodwork 01:23:06 Testosterone Supplement: Tongkat Ali, Libido 01:27:24 Menstrual Cycle, Birth Control & Fertility 01:30:54 Cognitive Enhancement & Focus, Sleep, Stimulants: Caffeine 01:36:57 Adrenaline & Stimulants: Yohimbine, Rauwolscine 01:38:55 Adjusting Neurotransmitters: Alpha-GPC, L-Tyrosine; Layering Supplements 01:43:58 Cognitive, Mood & Metabolic Support: Omega-3 Fatty Acids 01:47:25 Food-Mimic Supplements, Protein 01:50:09 Kids, Aging & Supplements 01:55:25 A Rational Supplementation Protocol 01:58:36 Zero-Cost Support, YouTube Feedback, Spotify & Apple Reviews, Sponsors, Momentous, Social Media, Neural Network Newsletter The Huberman Lab podcast is for general informational purposes only and does not constitute the practice of medicine, nursing or other professional health care services, including the giving of medical advice, and no doctor/patient relationship is formed. The use of information on this podcast or materials linked from this podcast is at the user’s own risk. The content of this podcast is not intended to be a substitute for professional medical advice, diagnosis, or treatment. Users should not disregard or delay in obtaining medical advice for any medical condition they may have and should seek the assistance of their health care professionals for any such conditions. Title Card Photo Credit: Mike Blabac - https://www.blabacphoto.com