Effective preventive medicine requires addressing causal drivers of disease rather than waiting for risk thresholds to be met.

“it makes no sense that we would look at a causal driver of asbd in the case of apob and kind of take an approach of well being at the 20th percentile or the 30th percentile the 40th percentile is acceptable none of those things really make sense”

High-intensity interval training is the most effective form of exercise for reducing the risk of cognitive decline.

“So, as you said, hit. Uh this this high-intensity interval training has turned out to be the one that seems to be the most effective at reducing your risk for cognitive decline.”

Regular self-monitoring of weight and body composition via bioimpedance scales is a key predictor of long-term weight maintenance.

“I think it's poss or something that said the people that measured their weight every day had a very significant advantage in keeping the weight off for the long term.”